Mechanisms of NLRP3 priming in inflammaging and age related diseases.
Mechanisms of NLRP3 priming in inflammaging and age related diseases.
复制标题
DOI：
10.1016/j.cytogfr.2020.08.003
复制
发表时间：
2020-10
影响因子：
13
通讯作者：
Lopez-Castejon G
中科院分区：
文献类型：
--
作者：
Gritsenko A;Green JP;Brough D;Lopez-Castejon G
衰老的过程与称为炎症的慢性炎症有关。炎症导致许多与年龄相关的疾病。由老化引发的NLRP 3炎性小体在转录、转录后和转录后驱动的生化变化。增强的NLRP 3炎性体活化可导致神经退行性和代谢性疾病以及癌症。NLRP 3炎性小体是先天免疫反应的重要组成部分，而其异常激活会导致许多非传染性疾病的进展。因此，NLRP 3炎性小体组装必须在几个检查点严格控制。NLRP 3炎性小体激活的引发步骤与增加的NLRP 3基因表达以及控制NLRP 3水平并许可NLRP 3蛋白进行炎性小体组装的翻译后修饰相关。现代社会预期寿命的增加伴随着老年人比例的增加。衰老过程与慢性炎症有关，慢性炎症会导致和/或加重一系列与年龄相关的非传染性疾病。已知NLRP 3炎性小体在许多情况下有助于病理性炎症，但在整个衰老过程中引发NLRP 3活化的机制和相关的共病尚未得到广泛的综述。在这里，我们剖析了衰老过程中发生的生化变化和年龄相关疾病的发病机制，并分析了它们引发NLRP 3炎性小体从而加剧炎症的机制。
The process of aging is associated with chronic inflammation termed inflammaging. Inflammaging drives a number of age related diseases. Biochemical changes driven by aging prime NLRP3 inflammasomes transcriptionally, post-transcriptionally and post-translationally. Enhanced NLRP3 inflammasome activation worsens neurodegenerative and metabolic conditions as well as cancer. The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant activation drives the progression of a number of non-communicable diseases. Thus, NLRP3 inflammasome assembly must be tightly controlled at several checkpoints. The priming step of NLRP3 inflammasome activation is associated with increased NLRP3 gene expression, as well as post-translational modifications that control NLRP3 levels and licence the NLRP3 protein for inflammasome assembly. Increasing life expectancy in modern society is accompanied by a growing percentage of elderly individuals. The process of aging is associated with chronic inflammation that drives and/or worsens a range of age related non-communicable conditions. The NLRP3 inflammasome is known to contribute to pathological inflammation in many settings, but the mechanisms that prime NLRP3 for activation throughout aging and related co-morbidities have not been extensively reviewed. Here we dissect the biochemical changes that occur during aging and the pathogenesis of age related diseases and analyse the mechanisms by which they prime the NLRP3 inflammasome, thus exacerbating inflammation.
登录
查看更多内容
影响因子：
14.9
作者：
CORTOPASSI, GA;ARNHEIM, N
通讯作者：
ARNHEIM, N
DOI：
10.1084/jem.20161707
发表时间：
2017-06-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Daley D;Mani VR;Mohan N;Akkad N;Pandian GSDB;Savadkar S;Lee KB;Torres-Hernandez A;Aykut B;Diskin B;Wang W;Farooq MS;Mahmud AI;Werba G;Morales EJ;Lall S;Wadowski BJ;Rubin AG;Berman ME;Narayanan R;Hundeyin M;Miller G
通讯作者：
Miller G
影响因子：
9.3
作者：
Cribbs DH;Berchtold NC;Perreau V;Coleman PD;Rogers J;Tenner AJ;Cotman CW
通讯作者：
Cotman CW
影响因子：
5.6
作者：
De Boer, Anna A.;Monk, Jennifer M.;Robinson, Lindsay E.
通讯作者：
Robinson, Lindsay E.
影响因子：
10.5
作者：
Chien, Yuchen;Scuoppo, Claudio;Lowe, Scott W.
通讯作者：
Lowe, Scott W.