Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas.
Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas.
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化学交换饱和转移（CEST）成像是一种重要的分子磁共振成像技术，它可以对大量低浓度的生物分子进行水交换质子成像CEST或更特别地酰胺质子转移加权（APTw）成像已广泛用于脑肿瘤的检测、诊断和反应评估，近年来，它在胶质瘤分子标志物鉴定中的可行性也得到了探索。本文在简要介绍CEST成像的基本原理和定量方法的基础上，综述了CEST成像在胶质瘤IDH突变、MGMT甲基化、1 p/19 q缺失和H3 K27 M突变检测中的早期应用。最后，我们将讨论这些研究的局限性或弱点。
Chemical exchange saturation transfer (CEST) imaging is an important molecular MRI technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST or more specially amide proton transfer-weighted (APTw) imaging has widely been used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing the basic principles and quantification methods of CEST imaging, we review its early applications in identifying IDH mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we will discuss the limitations or weaknesses in these studies.
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影响因子：
5.9
作者：
Fuster-Garcia E;Lorente Estellés D;Álvarez-Torres MDM;Juan-Albarracín J;Chelebian E;Rovira A;Acosta CA;Pineda J;Oleaga L;Mollá-Olmos E;Filice S;Due-Tønnessen P;Meling TR;Emblem KE;García-Gómez JM
通讯作者：
García-Gómez JM
DOI：
10.1158/1078-0432.ccr-18-1233
发表时间：
2019-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jiang S;Eberhart CG;Lim M;Heo HY;Zhang Y;Blair L;Wen Z;Holdhoff M;Lin D;Huang P;Qin H;Quinones-Hinojosa A;Weingart JD;Barker PB;Pomper MG;Laterra J;van Zijl PCM;Blakeley JO;Zhou J
通讯作者：
Zhou J
DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
影响因子：
3.3
作者：
Heo HY;Zhang Y;Jiang S;Lee DH;Zhou J
通讯作者：
Zhou J
影响因子：
3.3
作者：
Heo HY;Zhang Y;Burton TM;Jiang S;Zhao Y;van Zijl PCM;Leigh R;Zhou J
通讯作者：
Zhou J