Molecular epidemiology of COVID-19 in Oman: A molecular and surveillance study for the early transmission of COVID-19 in the country.
Molecular epidemiology of COVID-19 in Oman: A molecular and surveillance study for the early transmission of COVID-19 in the country.
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阿曼COVID-19的分子流行病学：该国COVID-19早期传播的分子和监测研究。
DOI：
10.1016/j.ijid.2020.12.049
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Al-Harrasi A
中科院分区：
文献类型：
--
作者：
Al-Mahruqi S;Al-Wahaibi A;Khan AL;Al-Jardani A;Asaf S;Alkindi H;Al-Kharusi S;Al-Rawahi AN;Al-Rawahi A;Al-Salmani M;Al-Shukri I;Al-Busaidi A;Al-Abri SS;Al-Harrasi A
严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 已被证明对人类健康具有致命性，几乎影响到世界每个角落。这项研究的目的是为全球数据和国际基因组联盟添加背景信息，并深入了解阿曼接触者追踪系统的效率。我们结合了阿曼 94 个 SARS-CoV-2 样本的流行病学数据和全基因组序列数据，以了解其起源、遗传变异和传播性。序列数据的全基因组大小是通过定制的 SARS-COV-2 研究小组获得的。放大器方法范围从 26 Kbp 到 30 Kbp，并已提交给 GISAID。研究发现，P323L（94.7%）是最常见的突变，其次是D614G（92.6%）Spike蛋白突变。一种独特的突变 I280V 首次在阿曼报道，与罕见谱系 B.1.113 (10.6%) 相关。此外，该研究揭示了遗传和流行病学数据之间的良好一致性。阿曼强大的监测系统在指导该国疫情调查过程方面非常有效，该研究说明了分子流行病学在领导国家应对疫情和大流行方面的未来重要性。
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been proven to be lethal to human health, which affects almost every corner of the world. The objectives of this study were to add context to the global data and international genomic consortiums, and to give insight into the efficiency of the contact tracing system in Oman. We combined epidemiological data and whole-genome sequence data from 94 samples of SARS-CoV-2 in Oman to understand the origins, genetic variation, and transmissibility. The whole-genome size of sequence data was obtained through a customized SARS-COV-2 research panel. Amplifier methods ranged from 26 Kbp to 30 Kbp and were submitted to GISAID. The study found that P323L (94.7%) is the most common mutation, followed by D614G (92.6%) Spike protein mutation. A unique mutation, I280V, was first reported in Oman and was associated with a rare lineage, B.1.113 (10.6%). In addition, the study revealed a good agreement between genetic and epidemiological data. Oman’s robust surveillance system was very efficient in guiding the outbreak investigation processes in the country, the study illustrates the future importance of molecular epidemiology in leading the national response to outbreaks and pandemics.
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影响因子：
5.2
作者：
Mercatelli, Daniele;Giorgi, Federico M.
通讯作者：
Giorgi, Federico M.
影响因子：
64.5
作者：
Volz E;Hill V;McCrone JT;Price A;Jorgensen D;O'Toole Á;Southgate J;Johnson R;Jackson B;Nascimento FF;Rey SM;Nicholls SM;Colquhoun RM;da Silva Filipe A;Shepherd J;Pascall DJ;Shah R;Jesudason N;Li K;Jarrett R;Pacchiarini N;Bull M;Geidelberg L;Siveroni I;COG-UK Consortium;Goodfellow I;Loman NJ;Pybus OG;Robertson DL;Thomson EC;Rambaut A;Connor TR
通讯作者：
Connor TR
影响因子：
0.8
作者：
Kandeil, Ahmed;Mostafa, Ahmed;Ali, Mohamed A.
通讯作者：
Ali, Mohamed A.
影响因子：
4.6
作者：
Tayoun AA;Loney T;Khansaheb H;Ramaswamy S;Harilal D;Deesi ZO;Varghese RM;Al Suwaidi H;Alkhajeh A;AlDabal LM;Uddin M;Hamoudi R;Halwani R;Senok A;Hamid Q;Nowotny N;Alsheikh-Ali A
通讯作者：
Alsheikh-Ali A
DOI：
10.1073/pnas.0508200103
发表时间：
2006-03-28
影响因子：
11.1
作者：
Minskaia, E;Hertzig, T;Ziebuhr, J
通讯作者：
Ziebuhr, J