Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring.

Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring.
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DOI:
10.1007/s13277-013-1141-0
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发表时间:
2014-01
期刊:
影响因子:
--
通讯作者:
Yao, Dengfu
Yao, Dengfu
中科院分区:
其他
文献类型:
--
作者:
Wang, Li;Yao, Min;Dong, Zhizhen;Zhang, Yun;Yao, Dengfu

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肝细胞癌(Hepatocellular carcinoma,HCC)是一种多因素、多步骤、复杂过程、预后差的常见恶性肿瘤。早期诊断和转移监测至关重要。肝癌组织合成各种肿瘤相关蛋白、基因、酶、microRNA等,然后分泌到血液中。循环生物标志物的检测有助于早期发现肿瘤或监测术后治疗后的转移。本文就近年来肝癌特异性生物标志物在肝癌早期诊断、转移监测及术后复发中的研究进展作一综述。
Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC.
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