Genetic association of impulsivity in young adults: a multivariate study.
Genetic association of impulsivity in young adults: a multivariate study.
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DOI：
10.1038/tp.2014.95
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发表时间：
2014-09-30
影响因子：
6.8
通讯作者：
Pearlson GD
中科院分区：
文献类型：
--
作者：
Khadka S;Narayanan B;Meda SA;Gelernter J;Han S;Sawyer B;Aslanzadeh F;Stevens MC;Hawkins KA;Anticevic A;Potenza MN;Pearlson GD
Impulsivity is a heritable, multifaceted construct with clinically relevant links to multiple psychopathologies. We assessed impulsivity in young adult (N~2100) participants in a longitudinal study, using self-report questionnaires and computer-based behavioral tasks. Analysis was restricted to the subset (N=426) who underwent genotyping. Multivariate association between impulsivity measures and single-nucleotide polymorphism data was implemented using parallel independent component analysis (Para-ICA). Pathways associated with multiple genes in components that correlated significantly with impulsivity phenotypes were then identified using a pathway enrichment analysis. Para-ICA revealed two significantly correlated genotype–phenotype component pairs. One impulsivity component included the reward responsiveness subscale and behavioral inhibition scale of the Behavioral-Inhibition System/Behavioral-Activation System scale, and the second impulsivity component included the non-planning subscale of the Barratt Impulsiveness Scale and the Experiential Discounting Task. Pathway analysis identified processes related to neurogenesis, nervous system signal generation/amplification, neurotransmission and immune response. We identified various genes and gene regulatory pathways associated with empirically derived impulsivity components. Our study suggests that gene networks implicated previously in brain development, neurotransmission and immune response are related to impulsive tendencies and behaviors.
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影响因子：
3.4
作者：
Dick DM;Smith G;Olausson P;Mitchell SH;Leeman RF;O'Malley SS;Sher K
通讯作者：
Sher K
影响因子：
3.3
作者：
Ciarleglio, C. M.;Resuehr, H. E. S.;McMahon, D. G.
通讯作者：
McMahon, D. G.
影响因子：
56.9
作者：
Birnbaum, SG;Yuan, PX;Arnsten, AFT
通讯作者：
Arnsten, AFT
影响因子：
6.9
作者：
Chamberlain, Samuel R.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.
影响因子：
3.3
作者：
Fineberg, Naomi A.;Chamberlain, Samuel R.;Goudriaan, Anna E.;Stein, Dan J.;Vanderschuren, Louk J. M. J.;Gillan, Claire M.;Shekar, Sameer;Gorwood, Philip A. P. M.;Voon, Valerie;Morein-Zamir, Sharon;Denys, Damiaan;Sahakian, Barbara J.;Moeller, F. Gerard;Robbins, Trevor W.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.