Molecular Portraits of Heterogeneity Related to Cancer Stem Cells in Human Ovarian Cancer
Molecular Portraits of Heterogeneity Related to Cancer Stem Cells in Human Ovarian Cancer
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人类卵巢癌中与癌症干细胞相关的异质性的分子肖像
DOI：
10.1097/igc.0000000000000024
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发表时间：
2014-01
影响因子：
4.8
通讯作者：
Shen, Keng
中科院分区：
文献类型：
--
作者：
Shi, Jie;Cui, Quancai;Yang, Jiaxin;Shen, Keng
目的探讨卵巢癌干细胞异质性的分子特征及其在诊断和治疗中的价值。方法收集20例浆液性卵巢乳头状腺癌行肿瘤细胞减灭术和再次减灭术的标本60例。免疫组织化学染色分析3种CSC标志物（CD 44、CD 133和CD 117）和3种干性蛋白（Bmi 1、Nestin和Oct 3/4）的表达密度和分布。两两比较它们在原发、转移和复发肿瘤中的表达。结果CD 133、CD 117等分子在1例组织中表达不同，除Oct 3/4外，其他分子在1例不同组织中表达不同。与原发性或转移性癌症相比，复发性癌症显示出更高的CD 133、CD 117和Bmi 1表达，以及更高的组织学分级。结论卵巢上皮性癌与肿瘤干细胞存在瘤内外异质性。这是值得进一步研究的。
Purpose The aim of this study was to investigate molecular portraits of heterogeneity related to cancer stem cells (CSCs) in human ovarian cancer and to access the value in diagnosis and treatment. Methods Sixty specimens were collected in both cytoreductive and re-cytoreductive surgeries of 20 serous papillary ovarian adenocarcinoma cases. Expression density and distribution of 3 CSC markers (CD44, CD133, and CD117) and 3 stemness proteins (Bmi1, Nestin, and Oct3/4) were analyzed by immunohistochemical staining. Pairwise comparisons were performed among their expression in primary, metastasis, and relapsing tumors. Results Some molecules presented different localization in 1 tissue, like CD133 and CD117, and all but Oct3/4 expressed differentially in different specimens of 1 case. Compared to primary or metastatic cancers, recurrent cancers show higher expression of CD133, CD117, and Bmi1, as well as higher histological grades. Conclusions Our study indicated that there exist extratumoral and intratumoral heterogeneity in ovarian epithelial cancers related to CSCs. And this is worth further studying.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
来自原发性人类肿瘤的卵巢癌起始细胞的鉴定和表征
影响因子：
11.2
作者：
Zhang, Shu;Balch, Curt;Nephew, Kenneth P.
通讯作者：
Nephew, Kenneth P.
影响因子：
2.6
作者：
Lu, Min;Glover, Clive H.;Helgason, Cheryl D.
通讯作者：
Helgason, Cheryl D.
Bmi-1 的强烈表达是卵巢癌患者预后不良的新独立预测因子。
影响因子：
3.8
作者：
Yang GF;He WP;Cai MY;He LR;Luo JH;Deng HX;Guan XY;Zeng MS;Zeng YX;Xie D
通讯作者：
Xie D
影响因子：
64.5
作者：
Lee, TI;Jenner, RG;Young, RA
通讯作者：
Young, RA