Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.
Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.
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Bmi-1 的强烈表达是卵巢癌患者预后不良的新独立预测因子。
DOI：
10.1186/1471-2407-10-133
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发表时间：
2010-04-08
期刊：
影响因子：
3.8
通讯作者：
Xie D
中科院分区：
文献类型：
--
作者：
Yang GF;He WP;Cai MY;He LR;Luo JH;Deng HX;Guan XY;Zeng MS;Zeng YX;Xie D
已有研究表明B细胞特异性莫洛尼白血病病毒插入位点1（Bmi-1）基因在多种人类肿瘤中发挥致癌作用，但Bmi-1在卵巢癌中的扩增和表达状况及其临床/预后意义尚不清楚。应用免疫组织化学和荧光原位杂交方法检测30例正常卵巢、30例卵巢囊腺瘤、40例卵巢交界性肿瘤和179例卵巢癌组织中Bmi-1蛋白的表达和扩增。Bmi-1在正常卵巢、3%的卵巢囊腺瘤、10%的交界性肿瘤和37%的卵巢癌中均未检测到强表达。在8%的卵巢癌中检测到Bmi-1扩增。在卵巢癌中，Bmi-1的强表达与肿瘤的组织学分级、pT/pN/pM及FIGO分期呈正相关（P < 0.05）。在卵巢癌组群的单变量生存分析中，Bmi-1的强表达与缩短的患者生存期显著相关（平均49.3个月对100.3个月，p < 0.001）。重要的是，Bmi-1表达在多变量分析中提供了显著的独立预后参数（p = 0.005）。这些发现提供了证据表明，Bmi-1的高表达可能在卵巢癌的侵袭性和/或侵袭性表型的获得中是重要的，并作为患者生存时间缩短的独立生物标志物。
It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas. Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005). These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients.
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DOI：
10.1007/s00432-007-0316-8
发表时间：
2008-05-01
影响因子：
3.6
作者：
Wang, Hui;Pan, Ke;Xia, Jian-chuan
通讯作者：
Xia, Jian-chuan
影响因子：
8.8
作者：
Vonlanthen S;Heighway J;Altermatt HJ;Gugger M;Kappeler A;Borner MM;van Lohuizen M;Betticher DC
通讯作者：
Betticher DC
影响因子：
23.4
作者：
van Leenders, Geert J. L. H.;Dukers, Danny;Raaphorst, Frank M.
通讯作者：
Raaphorst, Frank M.
Bmi-1的表达是膀胱癌的预后标志物
影响因子：
3.8
作者：
Qin ZK;Yang JA;Ye YL;Zhang X;Xu LH;Zhou FJ;Han H;Liu ZW;Song LB;Zeng MS
通讯作者：
Zeng MS
影响因子：
10.5
作者：
Lessard, J;Schumacher, A;Sauvageau, G
通讯作者：
Sauvageau, G