Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation.
Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation.
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DOI：
10.1016/j.chembiol.2022.04.006
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发表时间：
2022-05-19
影响因子：
8.6
通讯作者：
Hung, Deborah T.
中科院分区：
文献类型：
--
作者：
Warrier, Thulasi;Romano, Keith P.;Clatworthy, Anne E.;Hung, Deborah T.
20世纪40 - 60年代是抗生素发现的黄金时代，许多不同类别的抗生素的开发和应用，彻底改变了医学领域。从那时起，我们发现新结构类别或机制的抗生素的能力就跟不上不断增长的抗生素耐药性威胁。最近，在基因组学和化学生物学的交叉点的进展，使努力更好地定义的脆弱性的关键基因的目标，开发先进的全细胞化学筛选方法，揭示目标生物学的早期，并阐明小分子的目标和更有效的行动模式。这些新技术有可能扩大抗生素候选物的化学多样性以及靶标的广度。我们说明了基因组学和化学生物学的最新工具如何被整合，以更好地了解病原体的脆弱性和抗生素机制，以告知抗生素发现的新时代。在过去的50年里，我们发现新抗生素的能力没有跟上耐药性的演变。Escherer等人回顾了基因组学和化学生物学的最新工具如何被整合以了解病原体的脆弱性和抗生素机制，开创了抗生素发现的新时代。
The golden age of antibiotic discovery in the 1940–1960s saw the development and deployment of many different classes of antibiotics, revolutionizing the field of medicine. Since that time, our ability to discover antibiotics of novel structural classes or mechanisms has not kept pace with the ever-growing threat of antibiotic resistance. Recently, advances at the intersection of genomics and chemical biology have enabled efforts to better define the vulnerabilities of essential gene targets, to develop sophisticated whole cell chemical screening methods that reveal target biology early, and to elucidate small molecule targets and modes of action more effectively. These new technologies have the potential to expand the chemical diversity of antibiotic candidates, as well as the breadth of targets. We illustrate how the latest tools of genomics and chemical biology are being integrated to better understand pathogen vulnerabilities and antibiotic mechanisms in order to inform a new era of antibiotic discovery. In the last fifty years, our ability to discover novel antibiotics has not kept pace with the evolution of resistance. Warrier et al. review how the latest tools of genomics and chemical biology are being integrated to understand pathogen vulnerabilities and antibiotic mechanisms, fertilizing a new era of antibiotic discovery.
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影响因子：
6.7
作者：
Carey AF;Rock JM;Krieger IV;Chase MR;Fernandez-Suarez M;Gagneux S;Sacchettini JC;Ioerger TR;Fortune SM
通讯作者：
Fortune SM
DOI：
10.1073/pnas.83.16.6164
发表时间：
1986-08-01
影响因子：
11.1
作者：
DAVIS, BD;CHEN, LL;TAI, PC
通讯作者：
TAI, PC
影响因子：
4.9
作者：
BOURGUIG.GJ;LEVITT, M;STERNGLA.R
通讯作者：
STERNGLA.R
影响因子：
56.9
作者：
FLEISCHMANN, RD;ADAMS, MD;VENTER, JC
通讯作者：
VENTER, JC
影响因子：
4
作者：
Halouska, Steven;Fenton, Robert J.;Barletta, Raul G.;Powers, Robert
通讯作者：
Powers, Robert