Effect of neural crest ablation on development of the heart and arch arteries in the chick.
Effect of neural crest ablation on development of the heart and arch arteries in the chick.
复制标题
神经嵴消融对雏鸡心脏和弓动脉发育的影响。
DOI：
10.1002/aja.1001800403
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kirby,ML
中科院分区：
文献类型：
--
作者：
Bockman,DE;Redmond,ME;Waldo,K;Davis,H;Kirby,ML
神经嵴的间充质衍生物有助于咽弓的结缔组织和血管，并参与心脏流出道的分隔。本研究旨在确定神经嵴贡献减少后心脏和弓状动脉发育变化的性质和时间。在鸡胚中双侧消融了对三个尾侧咽弓有贡献的神经嵴，并与假手术或未手术对照组进行比较。通过扫描电子显微镜研究心脏发育。在血管内注射印度墨水并清除标本后，在显微镜下研究弓状动脉的发育。神经嵴消融引起大多数心脏的形态学改变。实验动物的心脏通常是细长的，心室和心房区域发育不适当。手术延迟了第一和第二弓状动脉的消失，切除神经嵴又延迟了消失。神经嵴消融导致一些动物的第三、第四（右）和第六弓状动脉未能发育到适当的大小。第六弓动脉达到适当大小的患者的存活率导致组测量值在第32阶段再次达到正常值。在某些动物中关闭弓状动脉，在其他动物中维持弓状动脉，实验动物的变异性比对照组更大。重要的是，心脏形态改变之前，正常发生的流出道分隔。这至少表明另一个因素，如血流改变，有助于异常发育。咽弓间充质和弓动脉内皮细胞的改变可能导致血流改变。
Mesenchymal derivatives of the neural crest contribute to the connective tissues and blood vessels of the pharyngeal arches, and participate in the septation of the outflow tract of the heart. The present study was designed to determine the nature and timing of alterations in the development of the heart and arch arteries subsequent to diminished neural crest contributions. The neural crest contributing to the three caudalmost pharyngeal arches was ablated bilaterally in chick embryos and compared with sham or unoper‐ated controls. Heart development was studied by scanning electron microscopy. Arch artery development was studied microscopically after intravascular injection of India ink and clearing of the specimen. Neural crest ablation caused morphological changes in most hearts. Hearts in experimental animals commonly were elongate and were subject to inappropriate development of ventricular and atrial areas. A surgical effect delayed the disappearance of arch arteries one and two, and removal of neural crest produced an additional delay. Neural crest ablation caused failure of arch arteries three, four (right), and six to develop to the proper size in some animals. Survival of those whose sixth arch arteries achieved the proper size caused group measurements to reach normal values again by stage 32. Closure of arch arteries in some animals and maintenance in others produced greater variability in experimental animals than in controls. It is significant that heart morphology was altered before septation of the outflow tract normally occurs. This indicates at the least that another factor, such as altered blood flow, contributes to the abnormal development. Altered flow may result from changes in pharyngeal arch mesenchyme and arch artery endothelium.
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影响因子：
5.2
作者：
J. Huber;P. Cholnoky;andH . E. Zoethout
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DOI：
--
发表时间：
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期刊：
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DOI：
10.1002/ar.1092080103
发表时间：
1984
期刊：
The Anatomical Record
影响因子：
--
作者：
D. Noden
通讯作者：
D. Noden
影响因子：
56.9
作者：
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通讯作者：
KIRBY, ML
DOI：
--
发表时间：
1970
期刊：
Advances in Morphogenesis
影响因子：
--
作者：
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