Highly fluorescent semiconducting polymer dots for biology and medicine.
Highly fluorescent semiconducting polymer dots for biology and medicine.
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DOI：
10.1002/anie.201205133
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发表时间：
2013-03-11
期刊：
影响因子：
--
通讯作者：
Chiu DT
中科院分区：
文献类型：
--
作者：
Wu C;Chiu DT
近年来，半导体聚合物纳米粒子由于其作为荧光探针的突出特性而引起了人们的广泛关注。这些纳米颗粒主要由π-共轭聚合物组成，当它们表现出小粒径和高亮度时被称为聚合物点（Pdot），已经在广泛的应用中证明了实用性，例如荧光成像和生物传感。在这篇综述中，我们总结了最近的研究结果Pdot的物理特性，这些实体作为荧光标记的优点。本文还重点介绍了Pdot的表面功能化和生物分子缀合，以及它们在细胞标记、体内成像、单粒子追踪、生物传感和药物递送中的应用。我们讨论的物理性质和性能之间的关系，并评估的优点和局限性的Pdot探针的某些成像任务和荧光检测。我们还解决了Pdot当前面临的挑战，并分享了我们对该领域未来发展方向的看法。半导体聚合物量子点作为一类新型的荧光纳米粒子，具有荧光亮度高、发射速率快、光稳定性好、不闪烁、无毒等特点。本文综述了聚合物点作为纳米粒子标记物在生物和医学应用中的最新进展（见图）。
In recent years, semiconducting polymer nanoparticles have attracted considerable attention because of their outstanding characteristics as fluorescent probes. These nanoparticles, which primarily consist of π-conjugated polymers and are called polymer dots (Pdots) when they exhibit small particle size and high brightness, have demonstrated utility in a wide range of applications such as fluorescence imaging and biosensing. In this review, we summarize recent findings of the photophysical properties of Pdots which speak to the merits of these entities as fluorescent labels. This review also highlights the surface functionalization and biomolecular conjugation of Pdots, and their applications in cellular labeling, in vivo imaging, single-particle tracking, biosensing, and drug delivery. We discuss the relationship between the physical properties and performance, and evaluate the merits and limitations of the Pdot probes for certain imaging tasks and fluorescence assays. We also tackle the current challenges of Pdots and share our perspective on the future directions of the field. As a new class of fluorescent nanoparticles, semiconducting polymer dots, exhibit excellent characteristics such as extraordinary fluorescence brightness, fast emission rates, excellent photostability, nonblinking, and nontoxicity. This review summarizes recent advances of the polymer dots as nanoparticle labels for biological and medical applications (see figure).
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