Estimating glomerular filtration rate in older people.
Estimating glomerular filtration rate in older people.
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DOI：
10.1155/2014/916542
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发表时间：
2014
影响因子：
--
通讯作者：
Lattanzio F
中科院分区：
文献类型：
--
作者：
Garasto S;Fusco S;Corica F;Rosignuolo M;Marino A;Montesanto A;De Rango F;Maggio M;Mari V;Corsonello A;Lattanzio F
我们的目的是审查与年龄相关的肾脏结构和功能的变化，估计肾功能的方法，肾功能下降对老年结局的影响，以及估计老年患者肾小球滤过率（eGFR）的方程的可靠性和适用性。CKD与不同的合并症和不良结局相关，如老年人群中的残疾和过早死亡。肌酐清除率和其他评估肾功能的方法不容易应用于老年受试者。因此，一个准确和可靠的方法计算eGFR将是非常可取的早期检测和管理CKD在这个脆弱的人群。基于血清肌酐、年龄、种族和性别的方程已被广泛使用。然而，这些方程有其自身的局限性，在老年人中似乎没有方程比其他方程更好。专门为老年人群开发的新方程，特别是基于血清胱抑素C的方程，有希望。然而，需要进一步的研究来明确接受它们作为在临床环境中估计老年患者肾功能的参考方法。
We aimed at reviewing age-related changes in kidney structure and function, methods for estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as well as the reliability and applicability of equations for estimating glomerular filtration rate (eGFR) in older patients. CKD is associated with different comorbidities and adverse outcomes such as disability and premature death in older populations. Creatinine clearance and other methods for estimating kidney function are not easy to apply in older subjects. Thus, an accurate and reliable method for calculating eGFR would be highly desirable for early detection and management of CKD in this vulnerable population. Equations based on serum creatinine, age, race, and gender have been widely used. However, these equations have their own limitations, and no equation seems better than the other ones in older people. New equations specifically developed for use in older populations, especially those based on serum cystatin C, hold promises. However, further studies are needed to definitely accept them as the reference method to estimate kidney function in older patients in the clinical setting.
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影响因子：
13.6
作者：
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