Journal of the Mechanical Behavior of Biomedical Materials Swelling of fi ber-reinforced soft tissues is a ff ected by fi ber orientation, fi ber sti ff ness, and lamella structure
Journal of the Mechanical Behavior of Biomedical Materials Swelling of fi ber-reinforced soft tissues is a ff ected by fi ber orientation, fi ber sti ff ness, and lamella structure
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生物医学材料机械行为杂志纤维增强软组织的膨胀受到纤维取向、纤维刚度和片层结构的影响
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通讯作者：
M A Adams
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作者：
D. McMillan;G. Garbutt;M A Adams
天然和工程纤维强化组织是由嵌入能够通过吸收水分子而膨胀的纤维外基质中的硬胶原纤维组成的复合材料。组织肿胀对于理解胶原纤维和纤维外基质之间的应力分布以及理解组织失效机制非常重要。肌肉骨骼系统中纤维增强组织的肿胀行为主要归因于糖胺聚糖含量。最近的研究表明，椎间盘纤维环的肿胀反应具有各向异性。众所周知，胶原纤维取向影响弹性行为，但胶原纤维网络对组织溶胀行为的影响还不清楚。在这项研究中，我们开发了三个系列的模型来评估胶原纤维取向，纤维网络结构（即，一层内的单纤维或多纤维家族），以及大块组织肿胀上的纤维硬度，其通过将额外的纤维基质描述为三相材料来模拟，如Lai等人提出的。模型结果在自由膨胀条件下组织体积、宽度和厚度变化的报告平均值的一个标准偏差内。单纤维家族结构的预测肿胀反应高度依赖于纤维方向和大块组织中的层数量。此外，基质肿胀导致组织扭曲，这减少了纤维变形，证明了纤维变形和基质肿胀之间的平衡。纤维硬度的较大变化（增加20倍）对组织肿胀的影响相对较小（肿胀减少约2%）。总之，纤维角度、纤维结构（定义为一层中的单纤维族与多纤维族）以及单纤维族结构中的层数直接影响组织肿胀行为，包括纤维拉伸、纤维重定向和组织变形。这些发现支持开发紧密模拟天然结构的计算模型的需要，以便理解应力分布和组织失效的机制。
Native and engineered fi ber-reinforced tissues are composites comprised of sti ff collagen fi bers embedded within an extra fi brillar matrix that is capable of swelling by absorbing water molecules. Tissue swelling is important for understanding stress distributions between collagen fi bers and extra fi brillar matrix, as well as for understanding mechanisms of tissue failure. The swelling behavior of fi ber-reinforced tissues in the musculoskeletal system has been largely attributed to the glycosaminoglycan content. Recent work demonstrated anisotropy in the swelling response of the annulus fi brosus in the intervertebral disc. It is well known that collagen fi ber orientation a ff ects elastic behavior, but the e ff ect of collagen fi ber network on tissue swelling behavior is not well understood. In this study, we developed three series of models to evaluate the e ff ect of collagen fi ber orientation, fi ber network architecture ( i.e. , single or multi- fi ber families within a layer), and fi ber sti ff ness on bulk tissue swelling, which was simulated by describing the extra fi brillar matrix as a triphasic material, as proposed by Lai et al. Model results were within one standard deviation of reported mean values for changes in tissue volume, width, and thickness under free swelling conditions. The predicted swelling response of single- fi ber family structures was highly dependent on fi ber orientation and the number of lamellae in the bulk tissue. Moreover, matrix swelling resulted in tissue to twist, which reduced fi ber deformations, demonstrating a balance between fi ber deformation and matrix swelling. Large changes in fi ber sti ff ness (20× increase) had a relatively small e ff ect on tissue swelling (~ 2% decrease in swelling). In conclusion, fi ber angle, fi ber architecture (de fi ned as single- versus multiple fi ber families in a layer), and the number of layers in a single fi ber family structure directly a ff ected tissue swelling behavior, including fi ber stretch, fi ber reorientation, and tissue deformation. These fi ndings support the need to develop computational models that closely mimic the native architecture in order to un- derstand mechanisms of stress distributions and tissue failure.
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影响因子：
2.4
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通讯作者：
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影响因子：
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作者：
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DOI：
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