MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level.
MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level.
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DOI：
10.3389/fmicb.2012.00306
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发表时间：
2012
影响因子：
5.2
通讯作者：
Okamoto T
中科院分区：
文献类型：
--
作者：
Tan Gana NH;Onuki T;Victoriano AF;Okamoto T
microRNA途径在转录水平上控制宿主和病毒的复杂相互作用，调节细胞反应、病毒复制和病毒发病机制。作为一组单链短的非编码核糖核苷酸（ncRNA），microRNA补充其信使RNA（mRNA）靶标以实现转录后或翻译基因沉默。先前的研究表明，人类免疫缺陷病毒1（HIV-1）能够编码microRNA，这些microRNA可以改变细胞防御机制，从而创造有利于病毒入侵和复制的环境。因此，细胞microRNA与HIV-1感染在不同复制阶段和潜伏期的改变有关。随着证据进一步确定细胞和病毒microRNA在HIV-1宿主相互作用中的调节参与，有必要组织这些信息。本文将介绍目前和新兴的知识，这些多维的相互作用，可能有助于设计的microRNA作为有效的抗逆转录病毒试剂。
The microRNA pathways govern complex interactions of the host and virus at the transcripts level that regulate cellular responses, viral replication and viral pathogenesis. As a group of single-stranded short non-coding ribonucleotides (ncRNAs), the microRNAs complement their messenger RNA (mRNA) targets to effect post-transcriptional or translational gene silencing. Previous studies showed the ability of human immunodeficiency virus 1 (HIV-1) to encode microRNAs which modify cellular defence mechanisms thus creating an environment favorable for viral invasion and replication. In corollary, cellular microRNAs were linked to the alteration of HIV-1 infection at different stages of replication and latency. As evidences further establish the regulatory involvement of both cellular and viral microRNA in HIV-1-host interactions, there is a necessity to organize this information. This paper would present current and emerging knowledge on these multi-dimensional interactions that may facilitate the design of microRNAs as effective antiretroviral reagents.
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影响因子：
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作者：
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DOI：
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期刊：
Biochimica et biophysica acta
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