Cannabis users demonstrate enhanced neural reactivity to reward: An event-related potential and time-frequency EEG study.
Cannabis users demonstrate enhanced neural reactivity to reward: An event-related potential and time-frequency EEG study.
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DOI：
10.1016/j.addbeh.2020.106669
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发表时间：
2021-03
影响因子：
4.4
通讯作者：
Shankman SA
中科院分区：
文献类型：
--
作者：
Crane NA;Funkhouser CJ;Burkhouse KL;Klumpp H;Phan KL;Shankman SA
一般来说，奖赏反应神经测量的中断与物质使用障碍（sud）的风险和发展有关，但尚不清楚大麻使用障碍（CUD）是否也是如此。迄今为止，还没有研究使用脑电图检查大麻使用者的神经奖励反应。大麻使用者（CU; n=67）和非使用者（n=60）是从有或没有内在化和外在化精神病理的个体的大型研究中抽取的。各组在当前和终生精神病理上进行匹配。参与者在脑电图（EEG）中完成了一个有效的金钱奖励任务。单向受试者间协方差分析（ANCOVA）模型检验了奖励反应的四项EEG指标——奖励正性（RewP）和反馈负性（FN）事件相关电位和两项时间-频率测量（奖励相关δ和损失相关θ）的组间差异。即使在控制了相关协变量之后，与非用户相比，CU证明了获得金钱奖励的RewP增强（p= 0.004）。二次分析发现，与非用户相比，偶尔的CU，而不是当前的CUD或缓解的CUD，显示出增强的RewP。两组之间FN、奖励相关的delta或损失相关的theta时间-频率测量没有显著差异。据我们所知，这是第一个初步证明CU具有增强的RewP奖励的研究，并且破坏的程度可能与CUD状态有关。我们的研究结果表明，更大的神经奖励反应可能只在偶尔的CU中看到，而不一定在当前或缓解的CU中看到。
Disruptions in neural measures of reward responsiveness are implicated in risk for and the development of Substance Use Disorders (SUDs) in general, but it is not clear if this is also true for Cannabis Use Disorder (CUD). To date, no studies have examined neural reward responsiveness in cannabis users using EEG. Cannabis users (CU; n=67) and non-users (n=60) were drawn from larger studies of individuals with and without internalizing and externalizing psychopathology. Groups were matched on current and lifetime psychopathology. Participants completed a validated monetary reward task during electroencephalogram (EEG). One-way between subject analysis of covariance (ANCOVA) models examined group differences in four EEG indicators of reward responsiveness - the reward positivity (RewP) and feedback negativity (FN) event-related potentials and two time-frequency measures (reward-related delta and loss-related theta). CU demonstrated an enhanced RewP to the attainment of monetary reward compared to non-users (p=.004), even after controlling for relevant covariates. Secondary analyses found that occasional CU, but not current CUD or remitted CUD, showed enhanced RewP compared to non-users. There were no significant differences in FN, reward-related delta, or loss-related theta time-frequency measures between groups. To our knowledge, this is the first study to show preliminary evidence that CU have an enhanced RewP to reward and the extent of disruption may be related to CUD status. Our findings suggest that greater neural reward responsiveness may only be seen among occasional CU, not necessarily among CU with current or remitted CUD.
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