A transcriptional profile of the decidua in preeclampsia.
A transcriptional profile of the decidua in preeclampsia.
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DOI：
10.1016/j.ajog.2010.08.043
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发表时间：
2011-01
影响因子：
9.8
通讯作者：
Austgulen R
中科院分区：
文献类型：
--
作者：
Løset M;Mundal SB;Johnson MP;Fenstad MH;Freed KA;Lian IA;Eide IP;Bjørge L;Blangero J;Moses EK;Austgulen R
利用基底蜕膜全基因组转录谱分析来深入了解先兆子痫潜在的可能机制。对先兆子痫（n = 37）和正常妊娠（n = 58）的基底蜕膜组织进行全基因组转录谱分析。差异表达的基因被鉴定并合并到典型的通路和网络中。在检测到的26,504个表达转录本中，有455个差异表达（P <0.05，FDR P <0.1）。两个新的（ARL5B，SLITRK4）和先前报道的先兆子痫相关基因（PLA2G7，HMOX1）进行了鉴定。途径分析显示，“色氨酸代谢”，“内质网应激”，“亚油酸代谢”，“缺口信号”，“脂肪酸代谢”，“花生四烯酸代谢”和“NRF2介导的氧化应激反应”是过度代表的经典途径。在本研究中，已经确定了可能在先兆子痫发病机制中起重要作用的单基因、典型途径和基因-基因网络。需要进一步的功能研究来更好地理解所涉及的机制。
To obtain insight into possible mechanisms underlying preeclampsia using genome-wide transcriptional profiling in decidua basalis. Genome-wide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal pregnancies (n = 58). Differentially expressed genes were identified and merged into canonical pathways and networks. Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P <0.05, FDR P <0.1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated genes (PLA2G7, HMOX1) were identified. Pathway analysis revealed that ‘tryptophan metabolism’, ‘endoplasmic reticulum stress’, ‘linoleic acid metabolism’, ‘notch signaling’, ‘fatty acid metabolism’, ‘arachidonic acid metabolism’ and ‘NRF2-mediated oxidative stress response’ were overrepresented canonical pathways. In the present study single genes, canonical pathways and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia, have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.
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DOI：
10.1177/1933719108322425
发表时间：
2008-11
期刊：
Reproductive sciences (Thousand Oaks, Calif.)
影响因子：
--
作者：
Mikheev AM;Nabekura T;Kaddoumi A;Bammler TK;Govindarajan R;Hebert MF;Unadkat JD
通讯作者：
Unadkat JD
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
3
作者：
Ackermann, Marit;Strimmer, Korbinian
通讯作者：
Strimmer, Korbinian
影响因子：
30.8
作者：
Goering, Harald H. H.;Curran, Joanne E.;Blangero, John
通讯作者：
Blangero, John
DOI：
10.1111/j.0001-6349.2004.00395.x
发表时间：
2004-08-01
影响因子：
4.3
作者：
Harsem, NK;Staff, AC;Roald, B
通讯作者：
Roald, B