Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study.
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study.
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DOI：
10.1177/1933719108322425
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Unadkat JD
中科院分区：
文献类型：
--
作者：
Mikheev AM;Nabekura T;Kaddoumi A;Bammler TK;Govindarajan R;Hebert MF;Unadkat JD
我们使用全基因组方法来确定其表达取决于胎龄的基因的主要功能类别。使用微阵列分析，我们比较了第一（45-59天）和第二个三个月（109-115天）胎盘绒毛组织与剖腹产足月胎盘的基因表达谱。我们发现，在孕早期胎盘，与细胞周期，DNA，氨基酸和碳水化合物代谢相关的基因显着过度表达，而与信号转导相关的基因表达不足。在参与生物防御的基因中，我们确定了参与化学反应、代谢和运输的基因。信号转导通路的分析表明，并随后独立证实，Wnt通路随胎龄变化，导致β-连环蛋白表达抑制。我们的研究将作为一个参考数据库，以深入了解基因表达的调控在发展中的胎盘，并比较基因表达的复杂妊娠胎盘。
We used the whole genome approach to identify major functional categories of genes whose expression depends on gestational age. Using microarray analysis, we compared gene expression profiles in the villous tissues of 1st (45-59 days) and 2nd trimester (109-115 days) placentae versus C-section term placentae. We found that in 1st trimester placentae, genes related to cell cycle, DNA, amino acids, and carbohydrate metabolism were significantly overrepresented, while genes related to signal transduction were underrepresented. Among genes involved in organism defense, we identified genes involved in chemical response, metabolism, and transport. Analysis of signal transduction pathways suggested, and subsequently confirmed independently, that the Wnt pathway was changed with gestational age leading to inhibition of β-catenin protein expression. Our study will serve as a reference database to gain insight into the regulation of gene expression in the developing placentae and to compare with gene expression in placentae from complicated pregnancies.
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影响因子：
2.3
作者：
Brown, LM;Lacey, HA;Crocker, IP
通讯作者：
Crocker, IP
影响因子：
3.8
作者：
Chan, CCW;Lao, TT;Cheung, ANY
通讯作者：
Cheung, ANY
DOI：
10.1073/pnas.231396598
发表时间：
2001-11-06
影响因子：
11.1
作者：
Hemberger, M;Cross, JC;Himmelbauer, H
通讯作者：
Himmelbauer, H
影响因子：
4
作者：
Takeda, T;Kurachi, H;Murata, Y
通讯作者：
Murata, Y
影响因子：
--
作者：
Biola, A;Lefebvre, P;Pallardy, M
通讯作者：
Pallardy, M