Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.
Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.
复制标题
DOI：
10.3390/molecules22071217
复制
发表时间：
2017-07-20
期刊：
影响因子：
--
通讯作者：
Scudiero O
中科院分区：
文献类型：
--
作者：
Falanga A;Nigro E;De Biasi MG;Daniele A;Morelli G;Galdiero S;Scudiero O
环肽类化合物由于其抗菌活性和高血清稳定性而受到广泛关注，这对于开发和设计新型抗菌剂是有用的。抗菌肽似乎是抵抗细菌、病毒和真菌的先天防御的关键组分。其中，防御素具有很强的杀微生物活性。防御素（Defensins）是一种阳离子两亲性多肽，具有六个半胱氨酸残基，通过三个二硫键连接，存在于植物、昆虫和哺乳动物中，分为α-、β-和θ-防御素三个家族。α-防御素包含在人嗜中性粒细胞的初级颗粒中; β-防御素在人上皮中表达; θ-防御素是在人中未发现但在恒河猴中发现的假环状防御素。三个家族之间的结构差异反映在不同的抗微生物作用以及血清稳定性中。这些肽的工程化是获得更多功能性抗微生物分子的令人兴奋的机会，突出了它们作为治疗剂的潜力。本文综述了环肽类化合物的最新研究进展，特别是防御素类似物。
Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents. Antimicrobial peptides appear to be key components of innate defences against bacteria, viruses, and fungi. Among the others, defensins possess a strong microbicidial activity. Defensins are cationic and amphipathic peptides with six cysteine residues connected by three disulfide bonds found in plants, insects, and mammals; they are divided in three families: α-, β-, and θ-defensins. α-Defensins are contained in the primary granules of human neutrophils; β-defensins are expressed in human epithelia; and θ-defensins are pseudo-cyclic defensins not found in humans, but in rhesus macaques. The structural diversities among the three families are reflected in a different antimicrobial action as well as in serum stability. The engineering of these peptides is an exciting opportunity to obtain more functional antimicrobial molecules highlighting their potential as therapeutic agents. The present review reports the most recent advances in the field of cyclic peptides with a specific regard to defensin analogs.
登录
查看更多内容
影响因子：
8
作者：
Galdiero E;Siciliano A;Maselli V;Gesuele R;Guida M;Fulgione D;Galdiero S;Lombardi L;Falanga A
通讯作者：
Falanga A
DOI：
10.3390/pathogens2010177
发表时间：
2013-03-19
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Cobo ER;Chadee K
通讯作者：
Chadee K
影响因子：
4.7
作者：
Danial, Maarten;van Dulmen, Tim H. H.;Klok, Harm-Anton
通讯作者：
Klok, Harm-Anton
影响因子：
5.6
作者：
Craik, DJ;Daly, NL;Waine, C
通讯作者：
Waine, C
影响因子：
5.6
作者：
Falanga A;Lombardi L;Franci G;Vitiello M;Iovene MR;Morelli G;Galdiero M;Galdiero S
通讯作者：
Galdiero S