Acupuncture Interventions for Alzheimer's Disease and Vascular Cognitive Disorders: A Review of Mechanisms.
Acupuncture Interventions for Alzheimer's Disease and Vascular Cognitive Disorders: A Review of Mechanisms.
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阿尔茨海默氏病和血管认知疾病的针灸干预措施：机制的综述。
DOI：
10.1155/2022/6080282
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发表时间：
2022
影响因子：
--
通讯作者：
Zhu, Guoqi
中科院分区：
文献类型：
--
作者：
Du, Kunrui;Yang, Shaojie;Wang, Jingji;Zhu, Guoqi
与阿尔茨海默病(AD)和血管性认知障碍(VCDs)相关的认知障碍(CI)已成为世界范围内的一个关键问题。重要的是，CI是一种以学习和记忆障碍为主要特征的神经精神异常。海马体是控制学习和记忆的重要大脑区域。最近的研究强调了针灸对AD和VCDs记忆缺陷的影响。本研究通过回顾近五年来有关这方面的文献，对针刺对AD和VCDs记忆障碍的影响进行综述。本文以海马区突触可塑性为研究对象，从突触蛋白、AD特征蛋白、肠道微生物区系、神经炎症、microRNA表达、食欲素系统、能量代谢等方面对针刺影响记忆障碍的机制进行了综述，认为海马区突触可塑性可能是上述机制的共同环节和核心环节。我们还讨论了提高针灸效果的潜在策略。此外，还进一步讨论了针刺通过调节血管-神经胶质-神经元单位对突触可塑性的影响。
Cognitive impairment (CI) related to Alzheimer's disease (AD) and vascular cognitive disorders (VCDs) has become a key problem worldwide. Importantly, CI is a neuropsychiatric abnormality mainly characterized by learning and memory impairments. The hippocampus is an important brain region controlling learning and memory. Recent studies have highlighted the effects of acupuncture on memory deficits in AD and VCDs. By reviewing the literature published on this topic in the past five years, the present study intends to summarize the effects of acupuncture on memory impairment in AD and VCDs. Focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, AD characteristic proteins, intestinal microbiota, neuroinflammation, microRNA expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. We also discussed the potential strategies to improve the effect of acupuncture. Additionally, the effects of acupuncture on synaptic plasticity through the regulation of vascular–glia–neuron unit were further discussed.
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DOI：
10.1001/jama.2017.3090
发表时间：
2017-04-11
期刊：
JAMA
影响因子：
--
作者：
Gottesman RF;Schneider AL;Zhou Y;Coresh J;Green E;Gupta N;Knopman DS;Mintz A;Rahmim A;Sharrett AR;Wagenknecht LE;Wong DF;Mosley TH
通讯作者：
Mosley TH
影响因子：
7.5
作者：
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通讯作者：
Du, Hongwu
影响因子：
2.7
作者：
Ardeshiri, Motahareh Rouhi;Hosseinmardi, Narges;Akbari, Esmaeil
通讯作者：
Akbari, Esmaeil
电针督脉腧穴对APP/PS1转基因小鼠行为变化及海马葡萄糖代谢的影响
影响因子：
4.8
作者：
Cao J;Tang Y;Li Y;Gao K;Shi X;Li Z
通讯作者：
Li Z
影响因子：
2.2
作者：
He C;Huang ZS;Yu CC;Wang XS;Jiang T;Wu M;Kong LH
通讯作者：
Kong LH