Expression analysis of SPARC/osteonectin in oral squamous cell carcinoma patients: from saliva to surgical specimen.
Expression analysis of SPARC/osteonectin in oral squamous cell carcinoma patients: from saliva to surgical specimen.
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DOI：
10.1155/2013/736438
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发表时间：
2013
影响因子：
--
通讯作者：
Longo F
中科院分区：
文献类型：
--
作者：
Aquino G;Sabatino R;Cantile M;Aversa C;Ionna F;Botti G;La Mantia E;Collina F;Malzone G;Pannone G;Losito NS;Franco R;Longo F
口腔鳞状细胞癌（OSCC）仍然是发病率和死亡率的重要原因，全球每年约有540，000例新发病例。与这种疾病的发病机制相关的分子机制仍然知之甚少。发现一种能够早期检测这种癌症的分子标记物是一项挑战，这种癌症可以在生物样品（如唾液）中容易地识别，而不需要干预晚期阶段。许多研究已经确定了一组在口腔鳞状细胞癌和正常口腔粘膜中表达不同的分子标志物。特别是，发现基质细胞糖蛋白γ的异常表达。它参与正常组织的重塑，调节细胞外基质的沉积，但也参与肿瘤转化。事实上，在与癌症相关的基质细胞和肿瘤细胞中均检测到异常表达。我们研究的目的是评估119例口腔鳞癌病例的回顾性系列，并验证27例口腔鳞癌患者的前瞻性系列所获得的数据，其中我们以前收集了唾液和涂片材料。所获得的结果相互关联，并与我们处理的临床病理参数。结果表明，PCNA在口腔鳞状细胞癌中的表达，尤其是在癌旁间质中的表达，对口腔鳞状细胞癌的预后有重要意义（P < 0.05）。
Oral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide. The molecular mechanisms related to the pathogenesis of this disease are still poorly understood. The discovery of a molecular marker that allows the early detection of this cancer, which can be easily identified in biological samples, such as saliva, without intervening in advanced stages, is a challenge. Numerous studies have identified a panel of molecular markers differently expressed in OSCC and normal oral mucosa. In particular, it was found an aberrant expression of matricellular glycoprotein SPARC. SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation. In fact, aberrant SPARC expression was detected both in stromal cells associated with cancer and in tumor cells. The aim of our study was the evaluation of SPARC on a retrospective series of 119 OSCC cases and the validation of the obtained data on a prospective series of 27 patients with OSCC, of whom we have previously collected saliva, and smeared material. The obtained results were correlated with each other and with clinical pathological parameters at our disposal. The study demonstrated a prognostic value of SPARC, especially with regard to its expression in the stroma surrounding OSCC (P < 0.05).
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影响因子：
4.8
作者：
DeRosa, C. A.;Furusato, B.;Petrovics, G.
通讯作者：
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