Comprehensive Wnt-related gene expression during cochlear duct development in chicken.
Comprehensive Wnt-related gene expression during cochlear duct development in chicken.
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DOI：
10.1002/cne.21791
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Fekete, Donna M.
中科院分区：
文献类型：
--
作者：
Sienknecht, Ulrike J.;Fekete, Donna M.
鸟类的耳蜗管容纳了前庭和听觉感觉器官（分别是黄斑腺和基底乳头），它们都有不同的结构和功能。在鸡耳蜗管发育的时间过程中进行的mRNA原位杂交比较图谱显示，wnt相关基因的表达伴随着多种发育过程，如耳蜗管区区化、耳蜗管的趋同延伸、细胞命运规范、突触发生以及平面细胞极性的建立。Wnt主要来源于非感觉组织域，而感觉原基优先转录卷曲受体，表明旁分泌Wnt信号在耳蜗管中占主导地位。叠加在此之上的是两种分泌的与卷曲相关的Wnt抑制剂的强表达，它们倾向于显示互补的表达模式。Frzb （SFRP3）局限于无感觉耳蜗管和黄斑韧带，而SFRP2与Fzd10和Wnt7b一起维持在基底乳头中。基底乳头两侧为：神经侧的Wnt7a、Wnt9a、Wnt11、SFRP2；以及神经外侧的Wnt5a， Wnt5b, Wnt7a。侧边无感觉耳蜗管持续表达Frzb，暂时表达Wnt6和SFRP1。整个藻丝的特征是Frzb的表达；黄斑藻中有Fzd1、Fzd7、Wnt7b；在非感觉组织中有Wnt4和Wnt5a。听觉毛细胞优先表达Fzd2和Fzd9，而前庭毛细胞除Fzd2和Fzd9外，主要表达受体为Fzd1和Fzd7。
The avian cochlear duct houses both a vestibular and the auditory sensory organ (the lagena macula and basilar papilla, respectively) that each have a distinct structure and function. Comparative mRNA in situ hybridization mappings conducted over the time course of chicken cochlear duct development reveal that Wnt-related gene expression is concomitant with various developmental processes such as regionalization, convergent extension of the cochlear duct, cell fate specification, synaptogenesis, and the establishment of planar cell polarity. Wnts mostly originate from nonsensory tissue domains while the sensory primordia preferentially transcribe Frizzled receptors, suggesting that paracrine Wnt signaling predominates in the cochlear duct. Superimposed over this is the strong expression of two secreted Frizzled-related Wnt inhibitors that tend to show complementary expression patterns. Frzb (SFRP3) is confined to the nonsensory cochlear duct and the lagena macula, whereas SFRP2 is maintained in the basilar papilla along with Fzd10 and Wnt7b. Flanking the basilar papilla are: Wnt7a, Wnt9a, Wnt11, and SFRP2 on the neural side; and Wnt5a, Wnt5b, Wnt7a on the abneural side. The lateral nonsensory cochlear duct continuously expresses Frzb and temporarily expresses Wnt6 and SFRP1. Characteristic for the entire lagena is the expression of Frzb; in the lagena macula are Fzd1, Fzd7, Wnt7b; and in the nonsensory tissues are Wnt4, Wnt5a. Auditory hair cells preferentially express Fzd2 and Fzd9, while the main receptors expressed in vestibular hair cells are Fzd1 and Fzd7, in addition to Fzd2 and Fzd9.
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影响因子：
1.4
作者：
COHEN, GM;FERMIN, CD
通讯作者：
FERMIN, CD
影响因子：
1.4
作者：
FERMIN, CD;COHEN, GM
通讯作者：
COHEN, GM
DOI：
10.1073/pnas.0402802101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Guo, N;Hawkins, C;Nathans, J
通讯作者：
Nathans, J
影响因子：
56.9
作者：
GRIER, JB;COUNTER, SA;SHEARER, WM
通讯作者：
SHEARER, WM
影响因子：
2.7
作者：
Abu-Elmagd, Muhammad;Garcia-Morales, Carla;Wheeler, Grant N.
通讯作者：
Wheeler, Grant N.