Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients.
Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes mellitus patients.
复制标题
在胰岛素依赖型糖尿病患者中，瘦素合成对胰岛素的急性作用具有抵抗力。
DOI：
--
复制
发表时间：
1997
影响因子：
5.8
通讯作者：
V. Koivisto
中科院分区：
文献类型：
--
作者：
J. Tuominen;P. Ebeling;U. Stenman;M. Heiman;T. Stephens;V. Koivisto
胰岛素刺激ob基因表达并增加小鼠和非胰岛素依赖型糖尿病患者的血清瘦素浓度。肥胖女性的ob基因信使核糖核酸水平高于肥胖男性，这表明性激素参与了瘦素合成的调节。我们研究了15名男性胰岛素依赖型糖尿病患者的瘦素、胰岛素和睾酮之间的关系（胰岛素依赖型糖尿病;年龄：29 ± 2岁;体重指数：22.7 ± 0.5 kg/m2;体脂：9.5 ± 1.0%;胰岛素剂量：44 ± 4 U/天;血红蛋白A1 c：8.1 ± 0.3%;糖尿病病程，12.7 ± 2.0年）和15名健康对照受试者（年龄，27 ± 1年;体重指数，22.6 ± 0.4 kg/m2;体脂，9.6 ± 0.5%）。此外，测定了4小时正常血糖高胰岛素血症（约600 pmol/L）对血浆瘦素浓度的影响。空腹瘦素水平与血浆睾酮水平呈负相关（r = -0.55; P < 0.05）。健康受试者空腹血浆瘦素水平升高25%（从1.0 ± 0.2 ng/mL升至1.3 ± 0.3 ng/mL; P < 0.05）。胰岛素依赖型糖尿病患者的瘦素水平较高（P < 0.01），在高胰岛素血症期间保持不变（2.7 +/- 0.2 vs 2.7 +/- 0.2 ng/mL）。我们得出了以下结论。1)在非肥胖的IDDM患者中，瘦素的合成对胰岛素的急性作用具有抵抗性。2)血清睾酮可能参与了胰岛素依赖型糖尿病患者瘦素合成的调节。
Insulin stimulates ob gene expression and increases serum leptin concentrations in mice and in noninsulin-dependent diabetes mellitus patients. Obese women have higher ob gene messenger ribonucleic acid levels than obese men, suggesting that sex hormones are involved in the regulation of leptin synthesis. We studied the relationship among leptin, insulin, and testosterone in 15 men with insulin-dependent diabetes mellitus (IDDM; age, 29 +/- 2 yr; body mass index, 22.7 +/- 0.5 kg/m2; body fat, 9.5 +/- 1.0%; insulin dose, 44 +/- 4 U/day; hemoglobin A1c, 8.1 +/- 0.3%; diabetes duration, 12.7 +/- 2.0 yr) and 15 healthy control subjects (age, 27 +/- 1 yr; body mass index, 22.6 +/- 0.4 kg/m2; body fat, 9.6 +/- 0.5%) in the fasting state. In addition, the effect of a 4-h euglycemic hyperinsulinemia (approximately 600 pmol/L) on the plasma leptin concentration was determined. The fasting leptin concentration was negatively correlated to plasma testosterone (r = -0.55; P < 0.05) in IDDM patients. The fasting plasma leptin level rose 25% in healthy subjects (from 1.0 +/- 0.2 to 1.3 +/- 0.3 ng/mL; P < 0.05). The leptin levels were higher in IDDM subjects (P < 0.01) and remained unchanged (2.7 +/- 0.2 vs. 2.7 +/- 0.2 ng/mL) during hyperinsulinemia. We reached the following conclusions. 1) In nonobese IDDM patients, leptin synthesis is resistant to the acute effect of insulin. 2) Serum testosterone may contribute to the regulation of leptin synthesis in IDDM patients.
影响因子：
15.9
作者：
Sinha, MK;Ohannesian, JP;Caro, JF
通讯作者：
Caro, JF
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF