Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species.
Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species.
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DOI：
10.3390/ijms222313022
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发表时间：
2021-12-01
影响因子：
5.6
通讯作者：
Nakano K
中科院分区：
文献类型：
--
作者：
Nagasawa Y;Nomura R;Misaki T;Ito S;Naka S;Wato K;Okunaka M;Watabe M;Fushimi K;Tsuzuki K;Matsumoto-Nakano M;Nakano K
伊加肾病（IgAN）一直被认为与扁桃体感染有关，因为IgAN患者经常在扁桃体炎后出现肉眼血尿。在口腔区域感染方面，牙周细菌的红色复合物（牙龈卟啉单胞菌（P. gingivalis）、牙密螺旋体（T. denticola）和Tannerella pasthia（T.但是这些细菌和IgAN之间的关系仍然未知。本研究比较IgAN与扁桃体炎患者扁桃体中牙周细菌红色复合物的患病率。牙龈卟啉单胞菌诱导的IgAN的致病性通过用该细菌处理的小鼠模型证实。牙龈卟啉单胞菌和T. IgAN患者的扁桃体肥大率显著高于扁桃体炎患者（P < 0.001和P < 0.05）。总共有92%的扁桃体炎患者没有红色复合菌，而只有48%的IgAN患者有这些细菌。在小鼠中经鼻施用牙龈卟啉单胞菌引起系膜增殖（在施用后第28天和第42天p < 0.05;在第14天和第56天p <0.01）和伊加沉积（在施用后第42天和第56天p < 0.001）。扫描电镜观察发现，牙龈卟啉单胞菌感染小鼠肾脏系膜区广泛分布着高密度的电子致密存款。提示牙龈卟啉单胞菌参与了IgAN的发病机制。
IgA nephropathy (IgAN) has been considered to have a relationship with infection in the tonsil, because IgAN patients often manifest macro hematuria just after tonsillitis. In terms of oral-area infection, the red complex of periodontal bacteria (Porphyromonas gingivalis (P. gingivalis), Treponema denticol (T. denticola) and Tannerella forsythia (T. forsythia)) is important, but the relationship between these bacteria and IgAN remains unknown. In this study, the prevalence of the red complex of periodontal bacteria in tonsil was compared between IgAN and tonsillitis patients. The pathogenicity of IgAN induced by P. gingivalis was confirmed by the mice model treated with this bacterium. The prevalence of P. gingivalis and T. forsythia in IgAN patients was significantly higher than that in tonsillitis patients (p < 0.001 and p < 0.05, respectively). A total of 92% of tonsillitis patients were free from red complex bacteria, while only 48% of IgAN patients had any of these bacteria. Nasal administration of P. gingivalis in mice caused mesangial proliferation (p < 0.05 at days 28a nd 42; p < 0.01 at days 14 and 56) and IgA deposition (p < 0.001 at day 42 and 56 after administration). Scanning-electron-microscopic observation revealed that a high-density Electron-Dense Deposit was widely distributed in the mesangial region in the mice kidneys treated with P. gingivalis. These findings suggest that P. gingivalis is involved in the pathogenesis of IgAN.
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DOI：
10.1093/ndt/gfu020
发表时间：
2014-08
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Kawamura T;Yoshimura M;Miyazaki Y;Okamoto H;Kimura K;Hirano K;Matsushima M;Utsunomiya Y;Ogura M;Yokoo T;Okonogi H;Ishii T;Hamaguchi A;Ueda H;Furusu A;Horikoshi S;Suzuki Y;Shibata T;Yasuda T;Shirai S;Imasawa T;Kanozawa K;Wada A;Yamaji I;Miura N;Imai H;Kasai K;Soma J;Fujimoto S;Matsuo S;Tomino Y;Special IgA Nephropathy Study Group
通讯作者：
Special IgA Nephropathy Study Group
影响因子：
3.7
作者：
Nagasawa Y;Yamamoto R;Shoji T;Shinzawa M;Hasuike Y;Nagatoya K;Yamauchi A;Hayashi T;Kuragano T;Moriyama T;Isaka Y;Nakanishi T
通讯作者：
Nakanishi T
影响因子：
4.6
作者：
Naka S;Wato K;Misaki T;Ito S;Matsuoka D;Nagasawa Y;Nomura R;Matsumoto-Nakano M;Nakano K
通讯作者：
Nakano K
影响因子：
4.6
作者：
Misaki T;Naka S;Hatakeyama R;Fukunaga A;Nomura R;Isozaki T;Nakano K
通讯作者：
Nakano K
影响因子：
3.7
作者：
Nagasawa Y;Iio K;Fukuda S;Date Y;Iwatani H;Yamamoto R;Horii A;Inohara H;Imai E;Nakanishi T;Ohno H;Rakugi H;Isaka Y
通讯作者：
Isaka Y