Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions.
Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions.
复制标题
DOI：
10.1038/srep36455
复制
发表时间：
2016-11-04
影响因子：
4.6
通讯作者：
Nakano K
中科院分区：
文献类型：
--
作者：
Misaki T;Naka S;Hatakeyama R;Fukunaga A;Nomura R;Isozaki T;Nakano K
变形链球菌是人类龋病的主要致病菌。携带cnm基因（编码Cnm，一种胶原结合蛋白）的菌株有助于几种全身性疾病的发展。在这项研究中，我们分析了S。从免疫球蛋白（IG）A肾病（IgAN）患者的口腔中分离的变异菌株，以确定cnm和龋齿状态以及IgAN状况之间的潜在关系。对109例IgAN患者的唾液标本进行了分离的S.使用PCR确定变形菌株。此外，在同意牙科咨询的患者（n = 49）的龋齿状态（龋齿，缺失或填充牙齿[DMFT]指数）进行了评价。cnm阳性组DMFT指数和尿蛋白水平显著高于cnm阴性组（p < 0.05）。高DMFT（≥15）组尿蛋白水平显著高于低DMFT（<15）组（p < 0.05）。我们的研究结果表明，cnm阳性S。来自口腔的变异株可能与IgAN患者的尿蛋白水平相关，特别是那些具有高龋齿状态的患者。
Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S. mutans strains was determined using PCR. In addition, the dental caries status (decayed, missing or filled teeth [DMFT] index) in patients who agreed to dental consultation (n = 49) was evaluated. The DMFT index and urinary protein levels in the cnm-positive group were significantly higher than those in the cnm-negative group (p < 0.05). Moreover, the urinary protein levels in the high DMFT (≥15) group were significantly higher than those in the low DMFT (<15) group (p < 0.05). Our results show that isolation of cnm-positive S. mutans strains from the oral cavity may be associated with urinary protein levels in IgAN patients, especially those with a high dental caries status.
登录
查看更多内容
影响因子：
3.3
作者：
Kusano, Kenichiro;Tokunaga, Osamu;Inokuchi, Akira
通讯作者：
Inokuchi, Akira
影响因子：
2.8
作者：
MIYATA, M;GLURICH, I;ALBINI, B
通讯作者：
ALBINI, B
影响因子：
3
作者：
Nomura, R.;Naka, S.;Nakano, K.
通讯作者：
Nakano, K.
影响因子：
3.7
作者：
Nagasawa Y;Iio K;Fukuda S;Date Y;Iwatani H;Yamamoto R;Horii A;Inohara H;Imai E;Nakanishi T;Ohno H;Rakugi H;Isaka Y
通讯作者：
Isaka Y
影响因子：
4.6
作者：
Kojima, Ayuchi;Nakano, Kazuhiko;Wada, Koichiro;Takahashi, Hirokazu;Katayama, Kazufumi;Yoneda, Masato;Higurashi, Takuma;Nomura, Ryota;Hokamura, Kazuya;Muranaka, Yoshinori;Matsuhashi, Nobuyuki;Umemura, Kazuo;Kamisaki, Yoshinori;Nakajima, Atsushi;Ooshima, Takashi
通讯作者：
Ooshima, Takashi