High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis.
High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis.
复制标题
高丰度的瘤内 γ δ T 细胞有利于头颈鳞状细胞癌更好的预后：生物信息分析
DOI：
10.3389/fimmu.2020.573920
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Lu H;Dai W;Guo J;Wang D;Wen S;Yang L;Lin D;Xie W;Wen L;Fang J;Wang Z
γδ T细胞是非常规T细胞的一个小子集，其在粘膜区域中富集，并且负责病原体清除和维持完整性。然而，γδ T细胞在头颈部鳞状细胞癌（HNSCC）中的作用在很大程度上是未知的。在这里，通过使用来自癌症基因组图谱（TCGA）的RNA-seq数据，我们发现具有较高水平的γδ T细胞的HNSCC患者与较低的临床分期和较好的总生存率呈正相关，并且高丰度的γδ T细胞与CD 8 +/CD 4 + T细胞浸润呈正相关。基因本体和途径分析表明，与T细胞活化、增殖、效应功能、细胞毒性和趋化因子产生相关的基因在具有较高γδ T细胞丰度的组中富集。此外，我们发现γδ T细胞的丰度与亲丁酸蛋白（BTN）家族蛋白BTN 3A 1/BTN 3A 2/BTN 3A 3和BTN 2A 1的表达呈正相关，但只有NKG 2D的配体之一MICB参与γδ T细胞的活化，表明BTN家族蛋白可能参与HNSCC肿瘤微环境中γδ T细胞的活化和增殖。我们的研究结果表明，γδ T细胞，沿着其配体，是HNSCC中有希望的靶点，具有很大的预后价值和治疗潜力。
γδ T cells are a small subset of unconventional T cells that are enriched in the mucosal areas, and are responsible for pathogen clearance and maintaining integrity. However, the role of γδ T cells in head and neck squamous cell carcinoma (HNSCC) is largely unknown. Here, by using RNA-seq data from The Cancer Genome Atlas (TCGA), we discovered that HNSCC patients with higher levels of γδ T cells were positively associated with lower clinical stages and better overall survival, and high abundance of γδ T cells was positively correlated with CD8+/CD4+ T cell infiltration. Gene ontology and pathway analyses showed that genes associated with T cell activation, proliferation, effector functions, cytotoxicity, and chemokine production were enriched in the group with a higher γδ T cell abundance. Furthermore, we found that the abundance of γδ T cells was positively associated with the expression of the butyrophilin (BTN) family proteins BTN3A1/BTN3A2/BTN3A3 and BTN2A1, but only MICB, one of the ligands of NKG2D, was involved in the activation of γδ T cells, indicating that the BTN family proteins might be involved in the activation and proliferation of γδ T cells in the tumor microenvironment of HNSCC. Our results indicated that γδ T cells, along with their ligands, are promising targets in HNSCC with great prognostic values and treatment potentials.
登录
查看更多内容
DOI：
10.4049/jimmunol.1203325
发表时间：
2013-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ammann JU;Cooke A;Trowsdale J
通讯作者：
Trowsdale J
影响因子：
--
作者：
Cai, Xiao-Yan;Wang, Jia-Xing;Qiu, Shuang-Jian
通讯作者：
Qiu, Shuang-Jian
影响因子：
4
作者：
Cai, Peian;Lu, Zhenhui;Zhao, Jinmin
通讯作者：
Zhao, Jinmin
影响因子：
4.4
作者：
Decaup, Emilie;Duault, Caroline;Fournie, Jean-Jacques
通讯作者：
Fournie, Jean-Jacques
影响因子：
7.2
作者：
Gruenbacher, Georg;Nussbaumer, Oliver;Thurnher, Martin
通讯作者：
Thurnher, Martin