Impaired receptivity and decidualization in DHEA-induced PCOS mice.
Impaired receptivity and decidualization in DHEA-induced PCOS mice.
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DHEA 诱导的 PCOS 小鼠感受性和蜕膜化受损。
DOI：
10.1038/srep38134
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发表时间：
2016-12-07
影响因子：
4.6
通讯作者：
Yang ZM
中科院分区：
文献类型：
--
作者：
Li SY;Song Z;Song MJ;Qin JW;Zhao ML;Yang ZM
多囊卵巢综合征（PCOS）是一种复杂的内分泌紊乱，是女性不孕的主要原因。PCOS妇女不孕的一个明显原因是无排卵。然而，PCOS患者通过辅助生殖技术选择高质量胚胎的成功率仍然很低，早期临床妊娠丢失率很高，这表明子宫容受性存在问题。使用脱氢表雄酮诱导的PCOS小鼠模型，探讨了PCOS患者生育能力下降的一些潜在原因。在我们的研究中，排卵问题也导致PCOS小鼠不育。将正常小鼠囊胚移植到假孕PCOS小鼠子宫腔内后，胚胎着床率降低。在PCOS小鼠子宫中，发育相关基因也失调。此外，人工蜕膜化在PCOS小鼠中严重受损。PCOS小鼠的血清雌激素水平显著高于溶剂对照组。高水平的雌激素和潜在的LIF-STAT 3通路受损可能导致PCOS小鼠胚胎着床失败。虽然关于PCOS对子宫内膜影响的研究很多，但本研究采用胚胎移植和人工蜕膜化两种方法来排除排卵和胚胎的影响。
Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study.
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影响因子：
6.1
作者：
Haoula, Zeina;Salman, Maisa;Atiomo, William
通讯作者：
Atiomo, William
影响因子：
6.1
作者：
Lédée-Bataille, N;Laprée-Delage, G;Chaouat, G
通讯作者：
Chaouat, G
影响因子：
5.8
作者：
Cermik, D;Selam, B;Taylor, HS
通讯作者：
Taylor, HS
DOI：
10.1073/pnas.151180898
发表时间：
2001-07-17
影响因子：
11.1
作者：
Cheng, JG;Chen, JR;Stewart, CL
通讯作者：
Stewart, CL
高脂肪饮食会在多囊卵巢综合症小鼠模型中引起显着的代谢紊乱
影响因子：
3.6
作者：
Lai, Hao;Jia, Xiao;Kang, Jihong
通讯作者：
Kang, Jihong