A Desaturative Approach for Aromatic Aldehyde Synthesis via Synergistic Enamine, Photoredox and Cobalt Triple Catalysis.
A Desaturative Approach for Aromatic Aldehyde Synthesis via Synergistic Enamine, Photoredox and Cobalt Triple Catalysis.
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DOI：
10.1002/anie.202201870
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发表时间：
2022-04-25
影响因子：
16.6
通讯作者：
Leonori, Daniele
中科院分区：
文献类型：
--
作者：
Zhao, Huaibo;Caldora, Henry P.;Turner, Oliver;Douglas, James J.;Leonori, Daniele
芳香的醛是基本的中间体，用于在整个化学工业中的重要材料的合成。这种新颖的策略。
协同的魔力，光氧氧和钴三重催化可以使芳香醛的制备方法。
Aromatic aldehydes are fundamental intermediates that are widely utilised for the synthesis of important materials across the broad spectrum of chemical industries. Accessing highly substituted derivatives can often be difficult as their functionalizations are generally performed via electrophilic aromatic substitution, SEAr. Here we provide an alternative and mechanistically distinct approach whereby aromatic aldehydes are assembled from saturated precursors via a desaturative process. This novel strategy harnesses the high‐fidelity of Diels–Alder cycloadditions to quickly construct multi‐substituted cyclohexenecarbaldehyde cores which undergo desaturation via the synergistic interplay of enamine, photoredox and cobalt triple catalysis. Synergistic enamine, photoredox and cobalt triple catalysis enables a desaturative approach for the preparation of aromatic aldehydes.
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影响因子：
2.6
作者：
Caldora, Henry P.;Govaerts, Sebastian;Leonori, Daniele
通讯作者：
Leonori, Daniele
DOI：
10.3390/molecules26164792
发表时间：
2021-08-07
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Ha MW;Paek SM
通讯作者：
Paek SM
影响因子：
5.2
作者：
Girard, Simon A.;Hu, Xiong;Li, Chao-Jun
通讯作者：
Li, Chao-Jun
影响因子：
5.2
作者：
Hajra, Alakananda;Wei, Ye;Yoshikai, Naohiko
通讯作者：
Yoshikai, Naohiko
影响因子：
2.7
作者：
Baumann M;Baxendale IR
通讯作者：
Baxendale IR