Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering.
Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering.
复制标题
导电生物材料作为用于伤口愈合和皮肤组织工程的生物活性伤口敷料
DOI：
10.1007/s40820-021-00751-y
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发表时间：
2021-12-02
影响因子：
26.6
通讯作者：
Guo B
中科院分区：
文献类型：
--
作者：
Yu R;Zhang H;Guo B
本文全面综述了用于伤口愈合的导电生物材料的设计和应用，包括多种导电剂、不同形式的导电伤口敷料以及体内的不同应用。讨论了导电生物材料在伤口愈合和皮肤组织工程中实现应用的三种主要策略。提出了设计多功能导电生物材料以及进一步临床转化所面临的挑战和展望。基于导电聚合物、碳纳米材料或导电无机纳米材料的导电生物材料由于与人体皮肤具有相似的导电性、良好的抗氧化和抗菌活性、电控药物递送以及光热效应，在伤口愈合和皮肤组织工程中显示出巨大潜力。然而，目前缺乏一篇关于导电生物材料在伤口愈合和皮肤组织工程中的设计和应用的综述。在本综述中，总结了具有薄膜、纳米纤维、膜、水凝胶、海绵、泡沫和无细胞真皮基质等多种结构形式的导电生物材料在伤口愈合和皮肤组织工程中的设计和制备方法，以及促进愈合过程的相应机制。综述了导电生物材料通过电疗、伤口敷料和伤口评估三种主要策略在伤口愈合中实现其巨大价值的方法。详细讨论了导电生物材料作为伤口敷料在面对不同伤口（包括急性伤口和慢性伤口（感染伤口和糖尿病伤口））时的应用以及用于伤口监测的情况。还提出了设计和开发多功能导电生物材料所面临的挑战和展望。
The design and application of conductive biomaterials for wound healing are comprehensively reviewed, including versatile conductive agents, the various forms of conductive wound dressings, and different in vivo applications. Three main strategies of which conductive biomaterials realizing their applications in wound healing and skin tissue engineering are discussed. The challenges and perspectives in designing multifunctional conductive biomaterials and further clinical translation are proposed. Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.
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影响因子：
10.8
作者：
Chiang, Wei-Lun;Lin, Tzu-Tsen;Sung, Hsing-Wen
通讯作者：
Sung, Hsing-Wen
影响因子：
13.6
作者：
Blacklow, S. O.;Li, J.;Mooney, D. J.
通讯作者：
Mooney, D. J.
DOI：
10.1002/advs.201600190
发表时间：
2017-02
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Cai G;Wang J;Qian K;Chen J;Li S;Lee PS
通讯作者：
Lee PS
影响因子：
6.6
作者：
Antonio, Jadielson L. S.;Lira, Luiz M.;Cordoba de Torresi, Susana I.
通讯作者：
Cordoba de Torresi, Susana I.
影响因子：
5
作者：
Aznar-Cervantes, Salvador;Roca, Maria I.;Otero, Toribio F.
通讯作者：
Otero, Toribio F.