Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice.
Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice.
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DOI：
10.1016/j.micinf.2017.08.013
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发表时间：
2017-12
影响因子：
5.8
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Wen Z;Wang X;Dong K;Zhang H;Bu Z;Ye L;Yang C
超过65岁的老年人处于流感病毒感染的发病率的极大风险中。然而，尽管流感疫苗在健康的年轻人中提供了有效的保护，但即使疫苗与流行的流感病毒之间具有良好的匹配，对老年人的保护也要低得多。为了深入了解流感疫苗在老年人群中免疫原性降低的潜在机制，我们研究了流感病毒样颗粒疫苗在老年小鼠中的免疫原性，这代表了研究免疫应答中与衰老相关的损伤的有用模型。具体而言，我们研究了抑制老年小鼠中调节性T细胞对流感疫苗诱导保护性免疫应答的影响。我们的结果表明，注射抗CD25抗体可以下调调节性T细胞表面的CD25，并显着增加VLP免疫诱导的抗体应答水平在老年小鼠。此外，在老年小鼠中，通过调节性T细胞阻断，抗体应答谱也向Th1型改变。此外，在接种疫苗之前用抗CD25抗体处理的老年小鼠更有效地保护免于致死性流感病毒攻击。
Elderly humans over 65 years old are at great risk to pathogenesis by influenza virus infection. However, although influenza vaccines provide effective protection in healthy young adults, protection of elderly adults is substantially lower even with a good match between the vaccine and the circulating influenza virus. To gain insight of the underlying mechanism for the reduced immunogenicity of influenza vaccines in the aged population, we investigated immunogenicity of influenza virus-like particle vaccines in aged mice, which represent a useful model for studying aging associated impairment in immune responses. Specifically, we investigated the effect of inhibiting regulatory T cells in aged mice on induction of protective immune responses by influenza vaccines. Our results showed that injecting anti-CD25 antibodies could down-regulate CD25 on the surface of regulatory T cells and significantly increase the levels of antibody responses induced by VLP immunization in aged mice. Further, the profiles of antibody responses were also changed towards Th1 type by regulatory T cell blockage in aged mice. Moreover, aged mice that were treated by anti-CD25 antibodies prior to vaccination were more effectively protected against lethal influenza virus challenge.
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影响因子：
13.2
作者：
Fang, Shisong;Bai, Tian;Yang, Lei;Wang, Xin;Peng, Bo;Liu, Hui;Geng, Yijie;Zhang, Renli;Ma, Hanwu;Zhu, Wenfei;Wang, Dayan;Cheng, Jinquan;Shu, Yuelong
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5.4
作者：
BEAN, WJ;SCHELL, M;WEBSTER, RG
通讯作者：
WEBSTER, RG
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作者：
Gibson KL;Wu YC;Barnett Y;Duggan O;Vaughan R;Kondeatis E;Nilsson BO;Wikby A;Kipling D;Dunn-Walters DK
通讯作者：
Dunn-Walters DK