Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection.
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection.
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DOI：
10.1002/jmv.23341
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发表时间：
2012-11
影响因子：
12.7
通讯作者：
Carvalho, Edgar M.
中科院分区：
文献类型：
--
作者：
Santos, Silvane Braga;Oliveira, Paulo;Luna, Tania;Souza, Anselmo;Nascimento, Marcia;Siqueira, Isadora;Tanajura, Davi;Muniz, Andre Luiz;Glesby, Marshall J.;Carvalho, Edgar M.
大多数感染人类T细胞淋巴病毒1型(HTLV-1)的患者被认为是携带者，但这些患者有较高频率的膀胱过度活动的尿路症状，这种症状常见于HTLV-1相关性脊髓病/热带痉挛麻痹(HAM/TSP)。这项研究的目的是确定HAM/TSP中出现的免疫和病毒因素是否也在这些患者中观察到。受试者分为HTLV-1携带者(n=45)、HTLV-1膀胱过度活动症患者(n=45)和HAM/TSP(n=45)。HTLV-1过度活跃患者的细胞自发产生比携带者更多的促炎细胞因子。HAM/TSP和HTLV-1膀胱过度活动症患者的肿瘤坏死因子-α和IL-17水平相似。膀胱过度活动者和HAM/TSP患者的前病毒负荷较高，且与促炎细胞因子有关。与HAM/TSP患者相比，HTLV-1过度活动组和携带者的血清Th1趋化因子水平相似。外源性细胞因子的加入减少了HTLV-1过度活动症患者细胞培养中自发的干扰素-γ的产生。结果表明，HTLV-1膀胱过度活动症和HAM/TSP患者具有共同的免疫学特征和相似的前病毒载量分布。数据显示，HTLV-1过度活跃的膀胱患者仍然能够下调其炎症免疫反应。此外，这些患者表达的趋化因子水平与携带者相似，这可能解释了为什么他们尚未出现与HAM/TSP患者相同程度的脊髓损伤。这些患者出现膀胱过度活动的症状，这可能是HAM/TSP的早期征兆。
The majority of patients infected with human T-cell lymphotropic virus-type 1 (HTLV-1) are considered carriers, but a high frequency of urinary symptoms of overactive bladder, common in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been documented in these patients. The aim of this study was to determine if immunological and viral factors that are seen in HAM/TSP are also observed in these patients. Participants were classified as HTLV-1 carriers (n=45), HTLV-1 patients suffering from overactive bladder (n=45) and HAM/TSP (n=45). Cells from HTLV-1 overactive bladder patients produced spontaneously more proinflammatory cytokines than carriers. TNF-α and IL-17 levels were similar in HAM/TSP and HTLV-1 overactive bladder patients. High proviral load was found in patients with overactive bladder and HAM/TSP and correlated with proinflammatory cytokines. In contrast with findings in patients with HAM/TSP, serum levels of Th1 chemokines were similar in HTLV-1 overactive bladder and carriers. Exogenous addition of regulatory cytokines decreased spontaneous IFN-γ production in cell cultures from HTLV-1 overactive bladder patients. The results show that HTLV-1 overactive bladder and HAM/TSP patients have in common some immunological features as well as similar proviral load profile. The data show that HTLV-1 overactive bladder patients are still able to down regulate their inflammatory immune response. In addition, these patients express levels of chemokines similar to carriers, which may explain why they have yet to develop the same degree of spinal cord damage as seen in patients with HAM/TSP. These patients present symptoms of overactive bladder, which may be an early sign of HAM/TSP.
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影响因子：
1.5
作者：
Caskey, Marina F.;Morgan, Daniel J.;Glesby, Marshall J.
通讯作者：
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影响因子：
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作者：
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DOI：
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作者：
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作者：
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