Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea?
Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea?
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DOI：
10.1113/expphysiol.2008.045153
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发表时间：
2009-03
影响因子：
2.7
通讯作者：
Narwani G
中科院分区：
文献类型：
--
作者：
Mateika JH;Narwani G
这篇综述主要集中在两个现象，开始期间和暴露后间歇性缺氧。这两种现象被称为呼吸运动输出的长期易化和渐进增强。这两种现象都是呼吸可塑性的表现形式。长期易化的特征是暴露于间歇性缺氧后呼吸活动持续升高。渐进性增强的特征在于从最初到最终低氧暴露的呼吸活动逐渐增加。有很多推测认为，长期易化可能在睡眠呼吸暂停患者中发挥重要作用，因为这种疾病的特征是上呼吸道塌陷伴间歇性缺氧，这是一种已知可诱导长期易化的刺激。有人认为，激活长期促进可能有助于缓解呼吸暂停，促进通气，更重要的是，上气道肌肉活动。我们研究了较少讨论但同样合理的情况，即暴露于间歇性缺氧可能最终导致呼吸暂停的促进。至少有两种情况下，呼吸暂停可能会促进暴露于间歇性缺氧。在这两种情况下，上呼吸道肌肉活动的长期促进开始，但最终由于其他生理条件而无效。因此，本综述的主要目标之一是讨论，在基础和临床研究的支持下，各种形式的呼吸运动神经元可塑性是否对睡眠呼吸暂停患者的呼吸稳定性产生有益和/或有害的影响。
This review focuses on two phenomena that are initiated during and after exposure to intermittent hypoxia. The two phenomena are referred to as long-term facilitation and progressive augmentation of respiratory motor output. Both phenomena are forms of respiratory plasticity. Long-term facilitation is characterized by a sustained elevation in respiratory activity after exposure to intermittent hypoxia. Progressive augmentation is characterized by a gradual increase in respiratory activity from the initial to the final hypoxic exposure. There is much speculation that long-term facilitation may have a significant role in individuals with sleep apnoea because this disorder is characterized by periods of upper airway collapse accompanied by intermittent hypoxia, one stimulus known to induce long-term facilitation. It has been suggested that activation of long-term facilitation may serve to mitigate apnoea by facilitating ventilation and, more importantly, upper airway muscle activity. We examine the less discussed but equally plausible situation that exposure to intermittent hypoxia might ultimately lead to the promotion of apnoea. There are at least two scenarios in which apnoea might be promoted following exposure to intermittent hypoxia. In both scenarios, long-term facilitation of upper airway muscle activity is initiated but ultimately rendered ineffective because of other physiological conditions. Thus, one of the primary goals of this review is to discuss, with support from basic and clinical studies, whether various forms of respiratory motor neuronal plasticity have a beneficial and/or a detrimental impact on breathing stability in individuals with sleep apnoea.
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DOI：
10.1046/j.1365-2281.1997.05353.x
发表时间：
1997-09-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
Appelberg, J;Sundstrom, G
通讯作者：
Sundstrom, G
影响因子：
2.3
作者：
Behan, M;Zabka, AG;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
2.3
作者：
Bradford, A;McGuire, M;O'Halloran, KD
通讯作者：
O'Halloran, KD
影响因子：
3.3
作者：
BADR, MS;TOIBER, F;DEMPSEY, J
通讯作者：
DEMPSEY, J
影响因子：
2.3
作者：
Diep, Tu Tuan;Khan, Tuba Rashid;Duffin, James
通讯作者：
Duffin, James