A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease.
A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease.
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用于阿尔茨海默病连接组成像的蓝斑通路到内嗅皮层的概率图谱
DOI：
10.1016/j.neuroimage.2020.117301
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发表时间：
2020-12
期刊：
影响因子：
5.7
通讯作者：
for Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Sun W;Tang Y;Qiao Y;Ge X;Mather M;Ringman JM;Shi Y;for Alzheimer's Disease Neuroimaging Initiative
根据阿尔茨海默病(AD)的最新Braak分期，tau的病理最早发生在脑干的蓝斑(LC)，然后扩散到经嗅觉皮质(TEC)，最后扩散到其他新皮质区域。最近的动物和活体人脑成像研究也支持tau病理的跨轴突传播。此外，神经化学研究将去甲肾上腺素与AD的行为症状联系起来。因此，在研究疾病的早期发展过程中，检查LC-TEC通路的完整性是至关重要的，但在这方面的工作有限。通过利用人类连接组计划(Human Connectome Project，HCP)的高分辨率和多层扩散磁共振数据，我们开发了一种新的方法，用于在40名HCP受试者中重建LC-TEC路径，该队列基于对脑干残余失真伪影的严格质量控制。然后，在MNI152空间开发了两个半球LC-TEC路径的概率图谱，并在NITRC网站上公开发布。为了将我们的图谱应用于临床影像数据，我们开发了一种自动方法来计算LC-TEC通路的内侧核心，用于局部分析连接性变化。在来自阿尔茨海默病神经成像计划(ADNI)的138名受试者中，我们发现随着疾病严重程度的增加，LC-TEC通路中的纤维完整性降低。
According to the latest Braak staging of Alzheimer’s disease (AD), tau pathology occurs earliest in the brain in the locus coeruleus (LC) of the brainstem, then propagates to the transentorhinal cortex (TEC), and later to other neocortical regions. Recent animal and in vivo human brain imaging research also support the trans-axonal propagation of tau pathology. In addition, neurochemical studies link norepinephrine to behavioral symptoms in AD. It is thus critical to examine the integrity of the LC-TEC pathway in studying the early development of the disease, but there has been limited work in this direction. By leveraging the high-resolution and multi-shell diffusion MRI data from the Human Connectome Project (HCP), in this work we develop a novel method for the reconstruction of the LC-TEC pathway in a cohort of 40 HCP subjects carefully selected based on rigorous quality control of the residual distortion artifacts in the brainstem. A probabilistic atlas of the LC-TEC pathway of both hemispheres is then developed in the MNI152 space and distributed publicly on the NITRC website. To apply our atlas on clinical imaging data, we develop an automated approach to calculate the medial core of the LC-TEC pathway for localized analysis of connectivity changes. In a cohort of 138 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), we demonstrate the detection of the decreased fiber integrity in the LC-TEC pathways with increasing disease severity.
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1712268115
发表时间：
2018-02-27
影响因子：
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作者：
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通讯作者：
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