Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events.
Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events.
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DOI：
10.1073/pnas.1712268115
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发表时间：
2018-02-27
影响因子：
11.1
通讯作者：
Düzel E
中科院分区：
文献类型：
--
作者：
Hämmerer D;Callaghan MF;Hopkins A;Kosciessa J;Betts M;Cardenas-Blanco A;Kanowski M;Weiskopf N;Dayan P;Dolan RJ;Düzel E
认知正常老年人的蓝斑（LC）完整性是痴呆的一个潜在的重要临床前标志物。我们的研究建立了LC完整性变异与老年去甲肾上腺素能调节相关的认知能力下降之间的联系。我们发现，在老年人中，LC完整性降低解释了较低的记忆性能。这种效应对于与负性事件相关的记忆更为明显，并且伴随着对负性事件反应的瞳孔直径大小的增加。该研究为未来研究LC完整性在健康以及病理衰老中的作用提供了强大的动力。蓝斑（LC）是大脑中去甲肾上腺素的主要来源。健康老年人的LC完整性差异很大，并且被认为有助于衰老时认知功能的改变。在这里，我们测试这一假设使用一个偶然的记忆任务，是已知的是易受去甲肾上腺素能调制。我们使用MRI神经黑色素（NM）成像来评估LC结构的完整性和瞳孔作为LC激活的推定指标在年轻人和老年人。我们发现，老年人与降低结构LC完整性显示较差的后续记忆。这种效应在情绪负面事件中更为明显，这与去甲肾上腺素能调节在编码显著或厌恶事件中的更大作用雅阁。此外，我们发现，显着的刺激导致更大的瞳孔直径，与增加LC激活过程中的编码这样的事件。我们的研究提供了新的证据，表明去甲肾上腺素能调节的减少影响健康老年人认知的特定组成部分。这些发现为进一步研究LC完整性改变对病理性衰老的影响提供了有力的动力。
Locus coeruleus (LC) integrity in cognitively normal older adults is a potentially important preclinical marker in dementia. Our study establishes a link between variability in LC integrity and cognitive decline related to noradrenergic modulation in old age. We find that in older adults, reduced LC integrity explains lower memory performance. This effect was more pronounced for memory related to negative events, and accompanied by increased pupil diameter size in response to negative events. The study provides a strong motivation for future research investigating the role of LC integrity in healthy, as well as in pathological, aging. The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC structural integrity and pupillometry as a putative index of LC activation in both younger and older adults. We show that older adults with reduced structural LC integrity show poorer subsequent memory. This effect is more pronounced for emotionally negative events, in accord with a greater role for noradrenergic modulation in encoding salient or aversive events. In addition, we found that salient stimuli led to greater pupil diameters, consistent with increased LC activation during the encoding of such events. Our study presents novel evidence that a decrement in noradrenergic modulation impacts on specific components of cognition in healthy older adults. The findings provide a strong motivation for further investigation of the effects of altered LC integrity in pathological aging.
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DOI：
10.1111/j.1749-6632.1985.tb37592.x
发表时间：
1985-01-01
影响因子：
5.2
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
7.8
作者：
Luo Y;Zhou J;Li MX;Wu PF;Hu ZL;Ni L;Jin Y;Chen JG;Wang F
通讯作者：
Wang F
影响因子：
56.9
作者：
BECHARA, A;TRANEL, D;DAMASIO, AR
通讯作者：
DAMASIO, AR
影响因子：
4.3
作者：
Mather M;Schoeke A
通讯作者：
Schoeke A
影响因子：
14.5
作者：
MANN, DMA;YATES, PO
通讯作者：
YATES, PO