The early generation of a heterogeneous CD4+ T cell response to Leishmania major.
The early generation of a heterogeneous CD4+ T cell response to Leishmania major.
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DOI：
10.4049/jimmunol.1000483
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发表时间：
2010-08-15
期刊：
影响因子：
--
通讯作者：
Scott P
中科院分区：
文献类型：
--
作者：
Colpitts SL;Scott P
CD4+ T细胞是主要利什曼原虫细胞内原生动物寄生虫初级和次级免疫反应的重要组成部分。我们的实验室之前已经证明CD62Lhigh IL7Rhigh central memory T （TCM）细胞在继发性攻击后介导保护性免疫。为了确定TCM细胞何时发育，我们在感染后的前两周检测了利什曼病毒特异性CD4+ T细胞的表型。正如预期的那样，我们在引流淋巴结中发现了具有效应T细胞特征的CD4+ T细胞群。然而，另外，与效应群体同时出现了表型类似TCM细胞的第二群体。这些表达CD62L、CCR7和IL7R的T细胞不能产生IFN-γ，但有能力产生产生IFN-γ的效应细胞。我们的研究还表明，增殖程度和进入淋巴结的时间影响中医细胞的发育。L. major感染后中医细胞的早期生成表明中医细胞不仅可以控制继发性感染，还可能有助于控制原发性感染。
CD4+ T cells are an essential component of both the primary and secondary immune response against the intracellular protozoan parasite Leishmania major. Our lab has previously shown that CD62Lhigh IL7Rhigh central memory T (TCM) cells mediate protective immunity following secondary challenge. To determine when TCM cells develop, we examined the phenotype of Leishmania-specific CD4+ T cells in the first two weeks following infection. As expected, we identified a population of CD4+ T cells present in the draining lymph node with the characteristics of effector T cells. However, in addition, a second population phenotypically resembling TCM cells emerged coincident with the effector population. These T cells, expressing CD62L, CCR7, and the IL7R, failed to produce IFN-γ but had the capacity to give rise to IFN-γ-producing effector cells. Our studies also demonstrated that the degree of proliferation and the timing of lymph node entry impact TCM cell development. The early generation of TCM cells following L. major infection indicates that TCM cells may not only control secondary infections, but may also contribute to the control of the primary infection.
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DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
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DOI：
10.1084/jem.20051954
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Catron DM;Rusch LK;Hataye J;Itano AA;Jenkins MK
通讯作者：
Jenkins MK
DOI：
10.4049/jimmunol.181.9.6473
发表时间：
2008-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carvalho LP;Pearce EJ;Scott P
通讯作者：
Scott P
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
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通讯作者：
Zajac, AJ