CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells.
CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells.
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抗原注射后进入排水淋巴结的CD4+ T细胞参与了主要反应并成为中央记忆细胞。
DOI：
10.1084/jem.20051954
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发表时间：
2006-04-17
期刊：
影响因子：
--
通讯作者：
Jenkins MK
中科院分区：
文献类型：
--
作者：
Catron DM;Rusch LK;Hataye J;Itano AA;Jenkins MK
我们探究了在初次免疫应答中初始CD4 + T细胞接触抗原的时间与所产生的记忆细胞质量之间的关系。皮下注射抗原后迁移到引流皮肤的淋巴结中的初始CD4 + T细胞约占克隆扩增高峰时存在的抗原特异性群体的一半。与抗原注射时就驻留在引流淋巴结中的T细胞相比，这些较晚到达的T细胞分裂次数更少，且更多地保留了中枢记忆标记CD62L。较少的细胞分裂与在应答中较早扩增的驻留T细胞的竞争以及抗原注射后较晚时间展示肽 - 主要组织相容性复合体（MHC）II复合物的树突状细胞数量减少有关。较晚到达的T细胞的后代具有中枢记忆细胞的表型，并且在二次应答期间比驻留T细胞的后代增殖更广泛。结果表明，在存在竞争T细胞的情况下较晚到达淋巴结以及接触展示较少数量肽 - MHC II复合物的抗原呈递细胞，确保了一些抗原特异性CD4 + T细胞在初次应答中分裂较少并成为中枢记忆细胞。
We explored the relationship between the time of naive CD4+ T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4+ T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central–memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide–major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central–memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide–MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4+ T cells divide less in the primary response and become central–memory cells.
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影响因子：
64.8
作者：
GALLATIN, WM;WEISSMAN, IL;BUTCHER, EC
通讯作者：
BUTCHER, EC
DOI：
10.1084/jem.20021690
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Reinhardt RL;Bullard DC;Weaver CT;Jenkins MK
通讯作者：
Jenkins MK
影响因子：
8.6
作者：
Powell, TJ;Brown, DM;Dutton, RW
通讯作者：
Dutton, RW
影响因子：
2.2
作者：
LYONS, AB;PARISH, CR
通讯作者：
PARISH, CR
DOI：
10.1084/jem.20042521
发表时间：
2005-05-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Obst R;van Santen HM;Mathis D;Benoist C
通讯作者：
Benoist C