ADP-ribosylation from molecular mechanisms to therapeutic implications.
ADP-ribosylation from molecular mechanisms to therapeutic implications.
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DOI：
10.1016/j.cell.2023.08.030
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发表时间：
2023-10-12
期刊：
影响因子：
64.5
通讯作者：
Ahel, Ivan
中科院分区：
文献类型：
--
作者：
Suskiewicz, Marcin J.;Prokhorova, Evgeniia;Rack, Johannes G. M.;Ahel, Ivan
adp核糖基化是一种普遍存在的生物分子修饰，包括蛋白质和核酸，在所有生命领域调节各种细胞功能。最近出现的研究adp核糖基化的新技术重塑了我们对这种修饰的建立、去除和识别的分子机制的理解，以及它对细胞和组织功能的影响。这些进展也揭示了adp核糖基化在人体生理和病理中的复杂参与，以及它们的操纵在治疗方面的巨大潜力。在这篇综述中，我们介绍了结构生物学、生物化学、细胞生物学和adp核糖基化临床方面的最新研究成果。蛋白质和核酸的adp核糖基化调节着所有生命王国的各种细胞功能，其操作具有人类治疗的潜力。在发现adp核糖基化60年后，本综述提供了结构生物学、生物化学、细胞生物学和临床方面的最新见解。
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent emergence of new technologies to study ADP-ribosylation has reshaped our understanding of the molecular mechanisms that govern the establishment, removal, and recognition of this modification, as well as its impact on cellular and organismal function. These advances have also revealed the intricate involvement of ADP-ribosylation in human physiology and pathology and the enormous potential that their manipulation holds for therapy. In this review, we present the state-of-the-art findings covering the work in structural biology, biochemistry, cell biology, and clinical aspects of ADP-ribosylation. ADP-ribosylation of proteins and nucleic acids regulates various cellular functions in all kingdoms of life, and its manipulation holds potential for human therapeutics. 60 years after the discovery of ADP-ribosylation, this review provides state-of-the-art insights on structural biology, biochemistry, cell biology, and clinical aspects.
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DOI：
10.1073/pnas.2302083120
发表时间：
2023-08-29
影响因子：
11.1
作者：
Alhammad, Yousef M.;Parthasarathy, Srivatsan;Ghimire, Roshan;Kerr, Catherine M.;O'Connor, Joseph J.;Pfannenstiel, Jessica J.;Chanda, Debarati;Miller, Caden A.;Baumlin, Nathalie;Salathe, Matthias;Unckless, Robert L.;Zuniga, Sonia;Enjuanes, Luis;More, Sunil;Channappanavar, Rudragouda;Fehr, Anthony R.
通讯作者：
Fehr, Anthony R.
影响因子：
64.5
作者：
Challa S;Khulpateea BR;Nandu T;Camacho CV;Ryu KW;Chen H;Peng Y;Lea JS;Kraus WL
通讯作者：
Kraus WL
影响因子：
7.3
作者：
Menzel S;Koudelka T;Rissiek B;Haag F;Meyer-Schwesinger C;Tholey A;Koch-Nolte F
通讯作者：
Koch-Nolte F
影响因子：
64.8
作者：
Ahel, Ivan;Ahel, Dragana;West, Stephen C.
通讯作者：
West, Stephen C.
影响因子：
4.6
作者：
Catara G;Grimaldi G;Schembri L;Spano D;Turacchio G;Lo Monte M;Beccari AR;Valente C;Corda D
通讯作者：
Corda D