Frontal parietal control network regulates the anti-correlated default and dorsal attention networks.
Frontal parietal control network regulates the anti-correlated default and dorsal attention networks.
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DOI：
10.1002/hbm.21204
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发表时间：
2012-01
影响因子：
4.8
通讯作者：
Lin, Weili
中科院分区：
文献类型：
--
作者：
Gao, Wei;Lin, Weili
最近的研究表明，背侧注意（DA）网络和缺省网络之间存在着反相关行为。我们的目的是通过三个实验条件，包括休息，连续自主/参与顺序手指敲击（FT），和自然电影观看（MW），分别调查的额叶-顶叶控制（FPC）网络在调节这两个反相关网络的作用。这两个目标导向的任务被选择来参与两个竞争网络中的任何一个-FT代表DA，而MW代表默认。我们假设FPC将根据任务如何针对特定网络选择性地增强/抑制任一网络; FPC将与目标网络正相关，但与目标网络反相关的网络负相关。我们进一步假设，在所有三个实验条件下，从FPC到DA和DF都存在显著的因果关系，支持FPC在两个相反系统中的主动调节作用。与我们的假设相一致，FPC表现出显着较高的正相关性DA（P = 0.0095），而显着更负相关性默认（P = 0.0025）在FT时相比，休息。与FT期间观察到的完全相反，FPC与DA显著反相关（P = 2.1e-6），而与MW期间的默认值正相关（P = 0.0035）。此外，广泛的因果关系，从FPC DA和DF观察到在所有三个实验状态。总之，我们的研究结果有力地支持了FPC调节反相关违约和DA网络的观点。
Recent reports demonstrate the anti-correlated behaviors between the default and the dorsal attention (DA) networks. We aimed to investigate the roles of the frontal parietal control (FPC) network in regulating the two anti-correlated networks through three experimental conditions, including resting, continuous self-paced/attended sequential finger tapping (FT), and natural movie watching (MW), respectively. The two goal-directed tasks were chosen to engage either one of the two competing networks—FT for DA whereas MW for default. We hypothesized that FPC will selectively augment/suppress either network depending on how the task targets the specific network; FPC will positively correlate with the target network, but negatively correlate with the network anti-correlated with the target network. We further hypothesized that significant causal links from FPC to both DA and DF are present during all three experimental conditions, supporting the initiative regulating role of FPC over the two opposing systems. Consistent with our hypotheses, FPC exhibited a significantly higher positive correlation with DA (P = 0.0095) whereas significantly more negative correlation with default (P = 0.0025) during FT when compared to resting. Completely opposite to that observed during FT, the FPC was significantly anti-correlated with DA (P = 2.1e-6) whereas positively correlated with default (P = 0.0035) during MW. Furthermore, extensive causal links from FPC to both DA and DF were observed across all three experimental states. Together, our results strongly support the notion that the FPC regulates the anti-correlated default and DA networks.
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DOI：
10.1073/pnas.0504136102
发表时间：
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影响因子：
11.1
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