Cerebral oxygen extraction fraction: Comparison of dual-gas challenge calibrated BOLD with CBF and challenge-free gradient echo QSM+qBOLD.
Cerebral oxygen extraction fraction: Comparison of dual-gas challenge calibrated BOLD with CBF and challenge-free gradient echo QSM+qBOLD.
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脑氧摄取分数：双气体激发校准BOLD与CBF和无激发梯度回波QSM+qBOLD的比较。
DOI：
10.1002/mrm.28447
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发表时间：
2021-03
影响因子：
3.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Cho J;Ma Y;Spincemaille P;Pike GB;Wang Y
比较两种MRI方法(1)定量磁化率标测加定量血氧水平依赖幅度(QSM+qBOLD或QQ)和2)双气体校准BOLD(DGCB)方法估计的健康受试者皮质灰质OEF，并探讨QQ在高碳酸血症时等CMRO2假设的有效性。10名健康受试者在高碳酸血症和高氧状态下进行3T磁共振成像，包括基线多回波GRE序列和高碳酸血症QQ，以及用于DGCB的EPI双回波伪连续动脉自旋标记(PCASL)。使用ROI分析和配对t检验比较QQ和DGCB的OEF。对于QQ，基线和高碳酸血症均产生CMRO2=CBF*OEF*Ca(Ca=动脉血氧含量)，并进行比较。10名QQ和DGCB受试者的皮质灰质(CGM)平均OEF在基线时分别为35.5±6.7和38.0±9.1%(P=0.49)，在高碳酸血症组分别为20.7±4.4和28.4±7.6%(P=0.02)：CGM的OEF在QQ和DGCB中均显著降低(P<0.01)。DGCB基础值为168.2±54.1cmRO2(μ摩尔O2/分钟/100g)，QQ法高碳酸血症患者基础值为153.1±33.8，高碳酸血症为126.4±34.2.QQ和DGCB测得的OEF在基线时差异很小且不显著，但在高碳酸血症时差异有统计学意义。此外，在高碳酸血症期间，QQ显示CMRO2降低17.4%。
To compare cortical gray matter OEF estimated from two MRI methods: 1) the quantitative susceptibility mapping plus quantitative blood oxygen level-dependent magnitude (QSM+qBOLD or QQ) and 2) the dual-gas calibrated-BOLD (DGCB) in healthy subjects, and to investigate the validity of iso-CMRO2 assumption during hypercapnia using QQ. In ten healthy subjects, 3T MRI including a multi-echo GRE sequence at baseline and hypercapnia for QQ, as well as an EPI dual-echo pseudo-continuous arterial spin labeling (pCASL) for DGCB were performed under a hypercapnic and a hyperoxic condition. OEFs from QQ and DGCB were compared using ROI analysis and paired t-test. For QQ, CMRO2=CBF*OEF*Ca (Ca=arterial oxygen content) was generated for both baseline and hypercapnia, which were compared. Average OEF in cortical gray matter (CGM) across 10 subjects from QQ vs DGCB were 35.5 ± 6.7 vs 38.0 ± 9.1 % (P=0.49) at baseline; and 20.7 ± 4.4 vs 28.4 ± 7.6 % (P=0.02) in hypercapnia: OEF in CGM was significantly reduced as measured in QQ (P<0.01) and in DGCB (P<0.01). CMRO2 (in μmol O2/min/100g) was 168.2 ± 54.1 at baseline from DGCB; and 153.1 ± 33.8 at baseline and 126.4 ± 34.2 (P<0.01) in hypercapnia from QQ. The differences in OEF obtained from QQ and DGCB are small and non-significant at baseline, but are statistically significant during hypercapnia. In addition, QQ shows a CMRO2 decrease (17.4%) during hypercapnia.
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影响因子：
4.3
作者：
Driver ID;Wise RG;Murphy K
通讯作者：
Murphy K
影响因子：
2.9
作者：
Blockley, Nicholas P.;Griffeth, Valerie E. M.;Simon, Aaron B.;Buxton, Richard B.
通讯作者：
Buxton, Richard B.
影响因子：
6.3
作者：
Jain, Varsha;Langham, Michael C.;Wehrli, Felix W.
通讯作者：
Wehrli, Felix W.
影响因子：
3.3
作者：
Cho J;Kee Y;Spincemaille P;Nguyen TD;Zhang J;Gupta A;Zhang S;Wang Y
通讯作者：
Wang Y
DOI：
10.1007/s00259-003-1430-8
发表时间：
2004-05-01
影响因子：
9.1
作者：
Ito, H;Kanno, I;Senda, M
通讯作者：
Senda, M