Neoadjuvant therapy for resectable pancreatic cancer.

Neoadjuvant therapy for resectable pancreatic cancer.
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DOI:
10.4251/wjgo.v9.i12.457
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发表时间:
2017-12-15
影响因子:
3
通讯作者:
Molinari M
Molinari M
中科院分区:
医学4区
文献类型:
--
作者:
Rahman SH;Urquhart R;Molinari M

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新辅助疗法的使用在临界可切除和局部晚期胰腺癌(PC)中发挥了重要作用。对于这组患者,术前化疗或放化疗增加了手术切缘阴性和总生存率的可能性。另一方面,对于可切除的前列腺癌患者,新辅助治疗的主要原因是目前策略的总生存率不令人满意。人们一致认为,我们需要新的治疗方法来提高 PC 患者的总体生存率和生活质量。然而,如果没有强有力的科学证据支持新辅助疗法的理论优势,这些潜在的好处可能不值得在等待手术期间冒肿瘤进展的风险。本文的重点是向读者提供有关该主题的最新证据的概述。
The use of neoadjuvant therapies has played a major role for borderline resectable and locally advanced pancreatic cancers (PCs). For this group of patients, preoperative chemotherapy or chemoradiation has increased the likelihood of surgery with negative resection margins and overall survival. On the other hand, for patients with resectable PC, the main rationale for neoadjuvant therapy is that the overall survival with current strategies is unsatisfactory. There is a consensus that we need new treatments to improve the overall survival and quality of life of patients with PC. However, without strong scientific evidence supporting the theoretical advantages of neoadjuvant therapies, these potential benefits might turn out not to be worth the risk of tumors progression while waiting for surgery. The focus of this paper is to provide the readers an overview of the most recent evidence on this subject.
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