IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus.
IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus.
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DOI：
10.1186/1476-4598-12-26
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发表时间：
2013-04-05
期刊：
影响因子：
37.3
通讯作者：
Lee KD
中科院分区：
文献类型：
--
作者：
Chen MF;Chen PT;Lu MS;Lin PY;Chen WC;Lee KD
潜在肿瘤标志物的识别可以改善治疗计划和患者管理。本研究的目的是强调 IL-6 在食管鳞状细胞癌 (SCC) 中的重要性。我们回顾性分析了 173 例食管鳞状细胞癌患者的临床结局，并探讨了食管癌患者 IL-6 水平与临床结局之间的相关性。此外，选择人食管鳞状细胞癌细胞系CE81T进行细胞和动物实验，以研究操纵IL-6表达后肿瘤行为和治疗反应的变化。在临床结果分析中，IL-6 染色阳性和治疗反应不佳与较短的生存期显着相关。此外，食管癌标本中IL-6免疫反应的频率显着高于非恶性上皮，并且这种染色与远处转移的发生（p = 0.0003）和较低的治疗反应率（p = 0.0001）呈正相关。通过ELISA分析，在疾病失败的患者中IL-6血清水平显着升高。当IL-6表达受到抑制时，侵袭性肿瘤行为和辐射耐受性可以在体外和体内克服。潜在的变化包括细胞死亡增加、上皮-间质转化减少和 STAT3 激活减弱。 IL-6 抑制也与荷瘤小鼠血管生成减弱有关。 IL-6与食管癌患者的不良预后显着相关。靶向这种细胞因子可能是治疗食管癌的一种有前途的策略，抑制肿瘤侵袭行为和治疗耐药性就证明了这一点。
The identification of potential tumor markers can improve therapeutic planning and patient management. The aim of this study was to highlight the significance of IL-6 in esophageal squamous cell carcinoma (SCC). We retrospectively analyzed the clinical outcomes of 173 patients with esophageal SCC, and examined the correlation between IL-6 levels and clinical outcomes in esophageal cancer patients. Furthermore, the human esophageal SCC cell line CE81T was selected for cellular and animal experiments to investigate changes in tumor behavior and treatment response after manipulation of IL-6 expression. In clinical outcome analysis, positive IL-6 staining and poor treatment response was significantly associated with shorter survival. Furthermore, the frequency of IL-6 immunoreactivity was significantly higher in esophageal cancer specimens than in non-malignant epithelium, and this staining was positively linked to the development of distant metastasis (p = 0.0003) and lower treatment response rates (p = 0.0001).By ELISA analysis, IL-6 serum levels were significantly elevated in patients developing disease failure.When IL-6 expression was inhibited, aggressive tumor behavior and radiation resistance could be overcome in vitro and in vivo. The underlying changes included increased cell death, less epithelial-mesenchymal transition and attenuated STAT3 activation. IL-6 inhibition was also associated with attenuated angiogenesis in tumor-bearing mice. IL-6 was significantly associated with poor prognosis in patients with esophageal cancer. Targeting this cytokine could be a promising strategy for treatment of esophageal cancer, as evidenced by inhibition of aggressive tumor behavior and treatment resistance.
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影响因子：
3.8
作者：
Kim DK;Oh SY;Kwon HC;Lee S;Kwon KA;Kim BG;Kim SG;Kim SH;Jang JS;Kim MC;Kim KH;Han JY;Kim HJ
通讯作者：
Kim HJ
影响因子：
8.8
作者：
Scambia, G.;Testa, U.;Benedetti Panici, P.;Foti, E.;Martucci, R.;Gadducci, A.;Perillo, A.;Facchini, V.;Peschle, C.;Mancuso, S.
通讯作者：
Mancuso, S.
DOI：
10.1016/j.ijrobp.2003.09.028
发表时间：
2004-02-01
影响因子：
7
作者：
Olive, PL;Banáth, JP
通讯作者：
Banáth, JP
影响因子：
6.4
作者：
Lee, Chien-Hung;Wu, Deng-Chyang;Wu, Ming-Tsang
通讯作者：
Wu, Ming-Tsang
影响因子：
4.7
作者：
Chen, Miao-Fen;Lee, Kuan-Der;Chen, Wen-Cheng
通讯作者：
Chen, Wen-Cheng