Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.
Combined Brain and Peripheral Nerve Stimulation in Chronic Stroke Patients With Moderate to Severe Motor Impairment.
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DOI：
10.1111/ner.12717
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Conforto AB
中科院分区：
文献类型：
--
作者：
Menezes IS;Cohen LG;Mello EA;Machado AG;Peckham PH;Anjos SM;Siqueira IL;Conti J;Plow EB;Conforto AB
评估重复周围神经感觉刺激 (RPSS) 结合经颅直流电刺激 (tDCS)、单独 tDCS、单独 RPSS 或假 RPSS+tDCS 形式的体感刺激作为功能性电刺激 (FES) 腕部伸展训练的附加干预措施，对患有中度至重度上肢损伤的慢性卒中患者的效果。 交叉设计。我们假设 RPSS 和 tDCS 的组合将比单独 RPSS、单独 tDCS 或假 RPSS+tDCS 更大程度地增强 FES 对瘫痪手腕主动运动范围 (ROM) 的影响。主要结果是瘫痪手腕的主动伸展活动度。次要结果是瘫痪和非瘫痪上肢的腕部屈曲活动范围、抓握和捏力，以及非瘫痪手腕的腕部伸展活动范围。在每次干预之前和之后对结果进行盲目评估。对因素“会话”和“时间”进行重复测量的方差分析。经过筛选 2499 名受试者后，其中 22 名被纳入。分析了 20 名受试者的数据。 “时间”对瘫痪肢体的抓握力和非瘫痪肢体的腕部伸展活动度有显着影响，但“会话”或交互作用“会话×时间”没有影响。 “会话”、“时间”或交互“会话×时间”对其他结果没有显着影响。单次 PSS+tDCS、单独 tDCS 或单独 RPSS 并不能改善中度至重度损伤的慢性卒中患者的训练效果。
To evaluate effects of somatosensory stimulation in the form of repetitive peripheral nerve sensory stimulation (RPSS) in combination with transcranial direct current stimulation (tDCS), tDCS alone, RPSS alone or sham RPSS+tDCS as add-on interventions to training of wrist extension with functional electrical stimulation (FES), in chronic stroke patients with moderate to severe upper limb impairments in a crossover design. We hypothesized that the combination of RPSS and tDCS would enhance the effects of FES on active range of movement (ROM) of the paretic wrist to a greater extent than RPSS alone, tDCS alone or sham RPSS+tDCS. The primary outcome was the active ROM of extension of the paretic wrist. Secondary outcomes were ROM of wrist flexion, grasp and pinch strength of the paretic and nonparetic upper limbs, and ROM of wrist extension of the nonparetic wrist. Outcomes were blindly evaluated before and after each intervention. Analysis of variance with repeated measures with factors “session” and “time” was performed. After screening 2499 subjects, 22 were included. Data from 20 subjects were analyzed. There were significant effects of “time” for grasp force of the paretic limb and for ROM of wrist extension of the nonparetic limb, but no effects of “session” or interaction “session × time”. There were no significant effects of “session”, “time” or interaction “session × time” regarding other outcomes. Single sessions of PSS+tDCS, tDCS alone or RPSS alone did not improve training effects in chronic stroke patients with moderate to severe impairment.
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影响因子：
8.3
作者：
Celnik, Pablo;Paik, Nam-Jong;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
3
作者：
Pandyan, AD;Cameron, M;Granat, MH
通讯作者：
Granat, MH
影响因子：
2.9
作者：
Liew SL;Santarnecchi E;Buch ER;Cohen LG
通讯作者：
Cohen LG
影响因子：
8.3
作者：
Carrico, Cheryl;Chelette, Kenneth C.;Sawaki, Lumy
通讯作者：
Sawaki, Lumy
影响因子：
14.5
作者：
Koganemaru, Satoko;Mima, Tatsuya;Domen, Kazuhisa
通讯作者：
Domen, Kazuhisa