Dental amalgam exposure and urinary mercury levels in children: the New England Children's Amalgam Trial.
Dental amalgam exposure and urinary mercury levels in children: the New England Children's Amalgam Trial.
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DOI：
10.1289/ehp.10440
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发表时间：
2008-02
影响因子：
10.4
通讯作者：
Barregard L
中科院分区：
文献类型：
--
作者：
Maserejian NN;Trachtenberg FL;Assmann SF;Barregard L
尿汞（U-Hg）排泄量是牙科汞合金治疗中汞暴露的常用生物标志物。我们的目标是确定牙科汞合金暴露的最有效措施，用于分析有关U-Hg的儿童。在为期5年的新英格兰儿童汞合金试验中，我们分析了随机接受汞合金治疗的儿童（n = 267）的时间敏感纵向汞合金暴露数据。我们计算了8项汞合金测量值，评估当前与累积暴露，牙齿与表面，以及总与后咬合汞合金。对随访3-5年期间采集的尿样进行汞排泄分析。当前和累积铀汞排泄的多变量模型估计了暴露与铀汞之间的关联。随访结束时，平均（± SD）累积暴露量为10.3 ± 6.1个表面和5.7 ± 2.9颗牙齿，用银汞合金填充，相当于30 ± 21个表面年。汞齐测量和U-Hg中度相关。汞合金暴露的措施，目前总的汞合金表面是最强大的预测目前的U-Hg，而后咬合面年是最好的累积U-Hg。在多变量模型中，每增加一个银汞合金表面与当前U-Hg增加9%相关，每增加一个后咬合面-年与累积U-Hg排泄增加3%相关（p < 0.001）。单一的汞合金暴露测量是不够的。如果采用对时间敏感的汞合金接触测量方法，儿童汞合金接触汞的累积效应研究可能会提高有效性和精确性。相比之下，对目前汞合金填充物的简单计数足以捕获与汞合金相关的铀汞。
Urinary mercury (U-Hg) excretion is a commonly used biomarker for mercury exposure from dental amalgam restorations. Our goal was to determine the most efficient measure of dental amalgam exposure for use in analyses concerning U-Hg in children. We analyzed time-sensitive longitudinal amalgam exposure data in children randomized to amalgam restorations (n = 267) during the 5-year New England Children’s Amalgam Trial. We calculated 8 measures of amalgam, evaluating current versus cumulative exposure, teeth versus surfaces, and total versus posterior occlusal amalgams. Urine samples collected during follow-up years 3–5 were analyzed for mercury excretion. Multivariate models for current and cumulative U-Hg excretion estimated associations between exposures and U-Hg. At the end of follow-up, the average (± SD) cumulative exposure was 10.3 ± 6.1 surfaces and 5.7 ± 2.9 teeth ever filled with amalgam, corresponding to 30 ± 21 surface-years. Amalgam measures and U-Hg were moderately correlated. Of amalgam exposure measures, the current total of amalgam surfaces was the most robust predictor of current U-Hg, whereas posterior occlusal surface-years was best for cumulative U-Hg. In multivariate models, each additional amalgam surface present was associated with a 9% increase in current U-Hg, and each additional posterior occlusal surface-year was associated with a 3% increase in cumulative U-Hg excretion (p < 0.001). One single measure of amalgam exposure is insufficient. Studies of cumulative effects of mercury from amalgam exposure in children are likely to have improved validity and precision if time-sensitive amalgam exposure measures are used. In contrast, simple counts of current amalgam fillings are adequate to capture amalgam-related current U-Hg.
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影响因子：
120.7
作者：
DeRouen, TA;Martin, MD;Martins, IP
通讯作者：
Martins, IP
DOI：
10.1016/s0197-2456(03)00105-3
发表时间：
2003-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
McKinlay, SM
通讯作者：
McKinlay, SM
影响因子：
9.8
作者：
Barregard, Lars;Horvat, Milena;Eugensson, Marie Haeger
通讯作者：
Eugensson, Marie Haeger
影响因子：
8.3
作者：
Levy, M;Schwartz, S;Rouah, F
通讯作者：
Rouah, F
DOI：
10.1034/j.1600-0528.2001.290309.x
发表时间：
2001-06-01
影响因子：
2.3
作者：
Diehnelt, DE;Kiyak, HA
通讯作者：
Kiyak, HA