Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review.
Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review.
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DOI：
10.3390/ma11020326
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发表时间：
2018-02-24
期刊：
影响因子：
--
通讯作者：
Bottagisio M
中科院分区：
文献类型：
--
作者：
Drago L;Toscano M;Bottagisio M
由创伤或病理事件引起的骨缺损是主要的临床和社会经济负担。因此，再生医学的努力一直集中在开发类似骨特征的非生物降解材料上。因此，生物活性玻璃作为一种有前途的替代惰性移植材料的使用已被提出。生物活性玻璃是一种合成硅基材料，具有优异的机械性能，能够与宿主骨组织结合。事实上，当浸入生理液体中时，生物活性玻璃发生反应，在颗粒表面形成磷灰石层，在骨生成过程中发挥关键作用。此外，生物活性玻璃与生物流体的接触由于离子从颗粒表面浸出而导致渗透压和pH增加，从而使周围环境不利于微生物生长。生物活性玻璃的抗微生物活性可有效对抗多种需氧和厌氧细菌，无论是嗜热菌还是固着菌。此外，明胶能够减少病原体的生物膜产生。出于上述原因，生物活性玻璃的使用可能是骨缺损重建以及治疗和根除以骨坏死和骨结构破坏为特征的骨感染的一个有前途的解决方案。
Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to inert graft materials has been proposed. Bioactive glass is a synthetic silica-based material with excellent mechanical properties able to bond to the host bone tissue. Indeed, when immersed in physiological fluids, bioactive glass reacts, developing an apatite layer on the granule’s surface, playing a key role in the osteogenesis process. Moreover, the contact of bioactive glass with biological fluids results in the increase of osmotic pressure and pH due to the leaching of ions from granules’ surface, thus making the surrounding environment hostile to microbial growth. The bioactive glass antimicrobial activity is effective against a wide selection of aerobic and anaerobic bacteria, either in planktonic or sessile forms. Furthermore, bioglass is able to reduce pathogens’ biofilm production. For the aforementioned reasons, the use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure.
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影响因子：
4.5
作者：
Cacciotti, Ilaria
通讯作者：
Cacciotti, Ilaria
影响因子：
3.7
作者：
Drago, Lorenzo;Romano, Delia;Romano, Carlo Luca
通讯作者：
Romano, Carlo Luca
影响因子：
3.1
作者：
Drago, Lorenzo;Vassena, Christian;Romano, Carlo Luca
通讯作者：
Romano, Carlo Luca
DOI：
10.1053/j.semtcvs.2015.12.005
发表时间：
2016-03-01
影响因子：
2.5
作者：
Elgharably, Haytham;Hussain, Syed T.;Pettersson, Gosta B.
通讯作者：
Pettersson, Gosta B.
DOI：
10.5507/bp.2005.019
发表时间：
2005-06-01
期刊：
Biomedical Papers (Olomouc)
影响因子：
--
作者：
Gallo, Jiri;Kolar, Milan;Kesselova, Michaela
通讯作者：
Kesselova, Michaela