Risk Factors Associated with Left-Sided Cardiac Valve Calcification: A Case Control Study
Risk Factors Associated with Left-Sided Cardiac Valve Calcification: A Case Control Study
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与左侧心脏瓣膜钙化相关的危险因素：病例对照研究
DOI：
10.1159/000443203
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发表时间：
2016-02
期刊：
影响因子：
1.9
通讯作者：
Sun, Wei
中科院分区：
文献类型：
--
作者：
Xuan, Qinkao;Shao, Yongfeng;Kong, Xiangqing;Sun, Wei
目的：确定与心脏瓣膜钙化相关的危险因素，在接受瓣膜置换治疗的患者中，通过常规血液测试可以很容易地发现这些危险因素。方法：选择2009年12月至2013年1月间接受瓣膜置换术的400例心脏瓣膜病患者作为研究对象。在这些人中，77人有瓣膜钙化；其余323人没有。多变量Logistic回归分析用于评估与瓣膜钙化相关的危险因素。结果：在我们的研究人群中，风湿性瓣膜病变是瓣膜置换术最常见的原因。退行性非狭窄瓣膜病变是瓣膜钙化的保护因素，退行性狭窄瓣膜病变是瓣膜钙化的重要危险因素。血清γ-谷氨酰转移酶水平在30~46IU/L和90IU/L之间，总胆红素水平在15~20μ/L之间，与瓣膜钙化呈正相关。同时，血清钙(Ca~(2+))水平在2.3~2.4 mmol/L之间与风湿性瓣膜钙化呈负相关。结论：退行性狭窄病变是心脏瓣膜钙化的危险因素，退行性非狭窄病变是瓣膜钙化的保护因素。血清GGT、TBIL水平与风湿性心脏瓣膜钙化呈正相关，血清钙水平与风湿性心脏瓣膜钙化呈负相关。
Objectives: To identify risk factors associated with cardiac valve calcification that is easily detectable through routine blood tests in patients who received valve replacement therapy. Methods: Four hundred patients with valvular heart disease who underwent valve replacement surgery between December 2009 and January 2013 were enrolled in this study. Of these, 77 had valve calcification; the other 323 did not. Multivariate logistic regression analysis was used to assess for risk factors associated with valve calcification. Results: In our study population, rheumatic valve lesions were the most common reason for valve replacement. Degenerative nonstenotic valve lesion was a protective factor and degenerative stenotic valve lesion was a strong risk factor for valve calcification. Serum levels of gamma-glutamyl transferase (GGT) of between 30 and 46 IU/l and >90 IU/l and total bilirubin (TBIL) of between 15 and 20 μmol/l were positively correlated with valve calcification. Meanwhile, serum calcium (Ca2+) levels of between 2.3 and 2.4 mmol/l were negatively correlated with rheumatic valve calcification. Conclusions: Degenerative stenotic lesion is a risk factor and degenerative nonstenotic lesion a protective factor for cardiac valve calcification. Serum GGT and TBIL levels are positively correlated and serum Ca2+ levels negatively correlated with rheumatic cardiac valve calcification.
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影响因子：
9.3
作者：
D. Lee;D. Jacobs;M. Gross;C. Kiefe;J. Roseman;C. Lewis;M. Steffes
通讯作者：
D. Lee;D. Jacobs;M. Gross;C. Kiefe;J. Roseman;C. Lewis;M. Steffes
影响因子：
5.6
作者：
Jansen T;Daiber A
通讯作者：
Daiber A
影响因子：
39.3
作者：
Shin, Sanghoon;Kim, Kwang-Joon;Chung, Namsik
通讯作者：
Chung, Namsik
影响因子：
5.3
作者：
Cappelli, Stefania;Epistolato, Maria Carmela;Tanganelli, Piero
通讯作者：
Tanganelli, Piero
DOI：
--
发表时间：
2008-07
期刊：
The Journal of heart valve disease
影响因子：
--
作者：
H. Bozbaş;A. Yıldırır;Ozlem Demir;Abdulkadir Çakmak;E. Karacaglar;M. Yılmaz;S. Eroglu;B. Pirat;B. Ozin;H. Muderrisoglu
通讯作者：
H. Bozbaş;A. Yıldırır;Ozlem Demir;Abdulkadir Çakmak;E. Karacaglar;M. Yılmaz;S. Eroglu;B. Pirat;B. Ozin;H. Muderrisoglu