CCR10 and its ligands in regulation of epithelial immunity and diseases.
CCR10 and its ligands in regulation of epithelial immunity and diseases.
复制标题
CCR10及其在调节上皮免疫和疾病中的配体。
DOI：
10.1007/s13238-012-2927-3
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发表时间：
2012-08
期刊：
影响因子：
21.1
通讯作者：
Yang, Jie
中科院分区：
文献类型：
--
作者：
Xiong, Na;Fu, Yaoyao;Hu, Shaomin;Xia, Mingcan;Yang, Jie
覆盖在身体外表面和内表面的上皮组织经常受到物理、化学或生物的攻击。为了保护上皮组织并维持其动态平衡，需要多层免疫防御机制。除了提供第一道防线的上皮组织驻留免疫细胞外，循环免疫细胞也被招募到局部组织中以应对挑战。趋化因子和趋化因子受体调节免疫细胞的组织特异性迁移、维持和功能。其中，趋化因子受体CCR10及其配体趋化因子CCL27和CCL28是唯一参与上皮免疫的分子。CCL27主要由角质形成细胞在皮肤中表达，而CCL28则由多种粘膜组织的上皮细胞表达。CCR10是由先天类T细胞的不同亚群表达的，这些T细胞在胸腺的发育过程中被编程定位于皮肤。循环T细胞可能被皮肤相关抗原提呈细胞印迹，以表达CCR10，以便在局部免疫反应中向皮肤募集。另一方面，在黏膜相关淋巴组织中产生的产生IgA抗体的B细胞表达CCR10，以促进其在黏膜部位的迁移和维持。越来越多的证据还发现，CCR10/配体参与了上皮免疫中其他免疫细胞的调节，并经常被上皮定位或起源的癌细胞利用，以求生存、增殖和逃避免疫监视。本文就CCR10/配体在上皮性免疫调节和疾病中的作用进行综述，并对相关值得进一步研究的重要问题进行推测。
Epithelial tissues covering the external and internal surface of a body are constantly under physical, chemical or biological assaults. To protect the epithelial tissues and maintain their homeostasis, multiple layers of immune defense mechanisms are required. Besides the epithelial tissue-resident immune cells that provide the first line of defense, circulating immune cells are also recruited into the local tissues in response to challenges. Chemokines and chemokine receptors regulate tissue-specific migration, maintenance and functions of immune cells. Among them, chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial immunity. CCL27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal tissues. CCR10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the thymus. Circulating T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune response. On the other hand, IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal sites. Increasing evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or -originated cancer cells for their survival, proliferation and evasion from immune surveillance. Herein, we will review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation.
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DOI：
10.1084/jem.20010670
发表时间：
2002-01-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bowman EP;Kuklin NA;Youngman KR;Lazarus NH;Kunkel EJ;Pan J;Greenberg HB;Butcher EC
通讯作者：
Butcher EC
影响因子：
4.4
作者：
Eksteen, Bertus;Miles, Alice;Adams, David H.
通讯作者：
Adams, David H.
影响因子：
4.4
作者：
Feng, Ningguo;Jaimes, Maria C.;Greenberg, Harry B.
通讯作者：
Greenberg, Harry B.
影响因子：
30.5
作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
4.1
作者：
Hon, KLE;Leung, TF;Fok, TF
通讯作者：
Fok, TF