Descriptive and risk factor analysis of infantile cataracts: National Birth Defects Prevention Study, 2000-2011.
Descriptive and risk factor analysis of infantile cataracts: National Birth Defects Prevention Study, 2000-2011.
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DOI：
10.1002/ajmg.a.62546
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发表时间：
2022-02
影响因子：
2
通讯作者：
Browne, Marilyn L.
中科院分区：
文献类型：
--
作者：
Nalbandyan, Marine;Howley, Meredith M.;Cunniff, Christopher M.;Leckman-Westin, Emily;Browne, Marilyn L.
利用国家出生缺陷预防研究（NBDPS）数据，我们试图估计出生患病率，描述临床特征，并检查婴儿白内障的危险因素。我们使用研究地区符合NBDPS条件的白内障病例和活产婴儿的数量计算出生患病率。我们描述的情况下，婴儿的存在相关的同侧眼缺陷（IED）和非眼睛相关的重大出生缺陷。使用母亲暴露信息收集通过电话采访，我们进行了逻辑回归分析的受访病例和对照组。婴儿白内障的出生患病率为1.07/10 000活产。单侧白内障更常与IED相关，而双侧白内障的婴儿更常早产，足月低出生体重，或有非眼睛相关的重大出生缺陷。单侧白内障与母亲未生育呈正相关（校正比值比[aOR] = 1.61，95%置信区间[CI] = 1.18，2.20;参考：经产），而双侧白内障与母亲教育<12年呈正相关（aOR = 2.08，95% CI = 1.13，3.82;参考：教育>12年）和外国出生的出生（aOR = 1.92，95% CI = 1.04，3.52;参考：美国-出生（Born Nativity）目前的分析可以为未来的流行病学研究提供信息，这些研究旨在确定婴儿白内障与复杂的母亲暴露之间联系的潜在机制，例如教育水平较低和外国出生。
Using National Birth Defects Prevention Study (NBDPS) data, we sought to estimate birth prevalence, describe clinical characteristics, and examine risk factors for infantile cataracts. We calculated birth prevalence using the numbers of NBDPS-eligible cataract cases and live births in the study area. We described case infants by the presence of associated ipsilateral eye defects (IEDs) and non-eye-related major birth defects. Using maternal exposure information collected via telephone interview, we conducted logistic regression analyses among the interviewed cases and controls. Birth prevalence of infantile cataracts was 1.07/10,000 live births. Unilateral cataracts were more often associated with IEDs, while infants with bilateral cataracts were more often preterm, full-term with low birth weight, or had non-eye-related major birth defects. Unilateral cataracts were positively associated with maternal nulliparity (adjusted odds ratio [aOR] = 1.61, 95% confidence interval [CI] = 1.18, 2.20; reference: multiparity), whereas bilateral cataracts were positively associated with maternal education <12 years (aOR = 2.08, 95% CI = 1.13, 3.82; reference: education >12 years), and foreign-born nativity (aOR = 1.92, 95% CI = 1.04, 3.52; reference: U.S.-born nativity). The current analysis can inform future epidemiological studies aimed at identifying mechanisms underlying the associations between infantile cataracts and complex maternal exposures, such as lower levels of education and foreign-born nativity.
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影响因子：
13.7
作者：
Haargaard, B;Wohlfahrt, J;Melbye, M
通讯作者：
Melbye, M
影响因子：
2.1
作者：
Howley MM;Feldkamp ML;Papadopoulos EA;Fisher SC;Arnold KE;Browne ML;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
--
作者：
Bhatti, TR;Dott, M;Rasmussen, SA
通讯作者：
Rasmussen, SA
DOI：
10.1002/bdra.23360
发表时间：
2015-02-01
影响因子：
--
作者：
McNeese, Melanie L.;Selwyn, Beatrice Josephine;Waller, Dorothy Kim
通讯作者：
Waller, Dorothy Kim
影响因子：
9.8
作者：
Miller, David T.;Adam, Margaret P.;Ledbetter, David H.
通讯作者：
Ledbetter, David H.