Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study.
Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study.
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DOI：
10.1002/bdr2.1409
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发表时间：
2018-11-15
影响因子：
2.1
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Howley MM;Feldkamp ML;Papadopoulos EA;Fisher SC;Arnold KE;Browne ML;National Birth Defects Prevention Study
泌尿生殖系统感染 (GUI) 在性活跃的女性中很常见。然而，人们对与 GUI 相关的出生缺陷风险知之甚少。我们利用国家出生缺陷预防研究（一项基于人群的多中心病例对照研究）的数据，对 29,316 名出生缺陷病例和 11,545 名未受影响的对照者在怀孕前一个月至第三个月（围孕期）自我报告的母亲 GUI 进行了评估。我们计算了比值比 (OR) 和 95% 置信区间，以估计与 GUI 相关的 52 种主要结构性出生缺陷的风险。我们还计算了与每种 GUI 相关的出生缺陷风险：尿路感染 (UTI) 和性传播感染 (STI)。在我们的分析中，10% (n = 2,972) 的病例母亲和 9% (n = 1,014) 的对照母亲报告有围孕期 GUI。 GUI 与检查的 52 种出生缺陷中的 11 种显着相关（OR 范围为 1.19 至 2.26）：脑膨出、白内障、唇裂、食管闭锁、十二指肠闭锁/狭窄、小肠闭锁/狭窄、结肠闭锁/狭窄、横肢缺陷、室间隔缺损、 房室间隔缺损、继发孔房间隔缺损。围孕期 UTI 与 9 种出生缺陷显着相关（OR 范围为 1.21 至 2.48），围孕期 STI 与 4 种出生缺陷显着相关（OR 范围为 1.63 至 3.72）。虽然我们的分析中的 GUI 可能会出现错误分类，但我们的研究结果表明，围孕期的 GUI 可能会增加特定出生缺陷的风险。
Genitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs. Using data from the National Birth Defects Prevention Study, a multisite, population-based, case-control study, we assessed self-reported maternal GUIs in the month before through the third month of pregnancy (periconception) from 29,316 birth defect cases and 11,545 unaffected controls. We calculated odds ratios (ORs) and 95% confidence intervals to estimate the risk of 52 major structural birth defects associated with GUIs. We also calculated risk of birth defects associated with each type of GUI: urinary tract infection (UTI) and sexually transmitted infection (STI). In our analysis, 10% (n = 2,972) of case and 9% (n = 1,014) of control mothers reported a periconceptional GUI. A GUI was significantly associated with 11 of the 52 birth defects examined (ORs ranging from 1.19 to 2.26): encephalocele, cataracts, cleft lip, esophageal atresia, duodenal atresia/stenosis, small intestinal atresia/stenosis, colonic atresia/stenosis, transverse limb deficiency, conoventricular septal defect, atrioventricular septal defect, and secundum atrial septal defect. A periconceptional UTI was significantly associated with nine birth defects (ORs from 1.21 to 2.48), and periconceptional STI was significantly associated with four birth defects (ORs ranging from 1.63 to 3.72). While misclassification of GUIs in our analysis is likely, our findings suggest GUIs during the periconceptional period may increase the risk for specific birth defects.
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DOI：
10.1002/bdra.20480
发表时间：
2008-08-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1002/bdra.20460
发表时间：
2008-06-01
影响因子：
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作者：
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通讯作者：
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