Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women.
Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women.
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DOI：
10.1016/j.ajog.2009.06.043
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发表时间：
2009-12
影响因子：
9.8
通讯作者：
Roberts, James M.
中科院分区：
文献类型：
--
作者：
Laughon, S. Katherine;Catov, Janet;Roberts, James M.
目的：探讨胰岛素抵抗孕妇尿酸水平是否升高，并与胎儿生长发育相关。测定263例妊娠20.4(±2.0)周孕妇的血尿酸、血糖和胰岛素水平。用稳态模型评估(HOMA)评估尿酸和胰岛素抵抗之间的关联，并与出生体重相关。在妊娠期间保持血压正常的212名妇女(80.6%)中，尿酸每增加1 mg/dl，HOMA就增加1.23U[(95%CI：1.07，1.42)，p=0.003]。血压正常的尿酸水平高四分位数和HOMA四分位数最低的妇女所生的婴儿比尿酸水平最高和HOMA四分位数高的妇女所生的婴儿体重轻435.6克(p<；0.005)。孕中期尿酸浓度升高与胰岛素抵抗有关。在血压正常的女性中，高尿酸血症与较低的出生体重有关，这种影响因胰岛素抵抗而减弱。
To investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth. Uric acid, glucose and insulin were measured in plasma at 20.4 (± 2.0) weeks gestation in 263 women. The association between uric acid and insulin resistance as estimated using the homeostasis model assessment (HOMA) was analyzed and related to birthweights. In 212 (80.6%) women who remained normotensive throughout pregnancy, HOMA increased 1.23 units per 1 mg/dl increase in uric acid [(95%CI: 1.07,1.42), p=0.003]. Infants born to normotensive women in the upper quartile of uric acid and lowest HOMA quartile weighed 435.6 grams less than infants of women with highest uric acid and HOMA quartiles (p < 0.005). Increasing uric acid concentrations were associated with insulin resistance in mid-pregnancy. Hyperuricemia was associated with lower birthweight in normotensive women, and this effect was attenuated by insulin resistance.
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影响因子：
3.5
作者：
Abuja, PM
通讯作者：
Abuja, PM
DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
Grundy, Scott M.
DOI：
10.1111/j.1471-0528.2005.00437.x
发表时间：
2005-04-01
影响因子：
5.8
作者：
Kristensen, J;Vestergaard, M;Secher, NJ
通讯作者：
Secher, NJ
影响因子：
5.8
作者：
Wolf, M;Sandler, L;Thadhani, R
通讯作者：
Thadhani, R
影响因子：
5.9
作者：
Choi, Hyon K.;Ford, Earl S.
通讯作者：
Ford, Earl S.