Translational suppression in gene expression in retroviruses and retrotransposons.

Translational suppression in gene expression in retroviruses and retrotransposons.
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逆转录病毒和逆转录转座子基因表达的翻译抑制。

DOI:
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发表时间:
1990
影响因子:
--
通讯作者:
T. Jacks
T. Jacks
中科院分区:
医学3区
文献类型:
--
作者:
T. Jacks

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The past 5 years have brought an exciting and very unexpected solution to a longstanding question in retrovirology: the mechanism of expression of the pol gene. Since the earliest studies of retroviral gene expression, the mechanism by which pol, the gene that encodes the critical enzymes reverse transcriptase, integrase, and sometimes protease, acts had remained an enigma. Experiments carried out recently seem to have finally settled this issue, as the pol genes of several retroviruses and one retrotransposon have been shown to be expressed by one or another form of translational suppression. This solution to the problem of pol gene expression is as unexpected as it is unusual. Even 5 year ago there was general agreement in this field that mRNA splicing would ultimately be found to be responsible for expression of the pol functions.
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