Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention-A Report from the 2021 National Heart, Lung, and Blood Institute Workshop.
Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention-A Report from the 2021 National Heart, Lung, and Blood Institute Workshop.
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DOI：
10.3390/jcm11195721
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发表时间：
2022-09-27
影响因子：
3.9
通讯作者：
Workshop Speakers
中科院分区：
文献类型：
--
作者：
Čiháková D;Shi Y;Adhikari B;Bandettini WP;Cunningham MW;Danthi N;Friedrich MG;Liu P;Longacre LS;Mann DL;Swirski FK;Tang WHW;Zhou G;Cooper LT Jr;Workshop Speakers
美国国家心脏、肺和血液研究所（NHLBI）于2021年5月召开了一次国际专家研讨会，讨论预防、检测和干预心肌炎的新研究机会。这些专家回顾了当前的科学状况，并确定了基础，诊断，转化和治疗前沿的关键差距和机会，以指导心肌炎的未来研究。除了解决社区获得性心肌炎，研讨会还重点关注心肌炎的新原因，包括免疫检查点抑制剂和SARS-CoV-2相关的心肌损伤，并考虑使用系统生物学和人工智能方法来定义工作流程，以确定疾病的新机制和新的治疗靶点。一个新的优先事项是调查健康的社会决定因素（SDoH），包括种族和经济地位，心肌炎的炎症反应和结果之间的关系。其结果是一个重新分类心肌炎的建议，整合了免疫发病机制的最新知识，以完善预后和靶向途径特异性治疗的估计。
The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments.
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DOI：
10.1038/s41379-021-00790-1
发表时间：
2021-07
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Bearse M;Hung YP;Krauson AJ;Bonanno L;Boyraz B;Harris CK;Helland TL;Hilburn CF;Hutchison B;Jobbagy S;Marshall MS;Shepherd DJ;Villalba JA;Delfino I;Mendez-Pena J;Chebib I;Newton-Cheh C;Stone JR
通讯作者：
Stone JR
影响因子：
18.2
作者：
Baritussio, Anna;Schiavo, Alessandro;Caforio, Alida Linda Patrizia
通讯作者：
Caforio, Alida Linda Patrizia
影响因子：
8
作者：
Adamo, Luigi;Rocha-Resende, Cibele;Mann, Douglas L.
通讯作者：
Mann, Douglas L.
影响因子：
37.8
作者：
CARLQUIST, JF;MENLOVE, RL;ANDERSON, JL
通讯作者：
ANDERSON, JL
影响因子：
4.4
作者：
Barin, Jobert G.;Baldeviano, G. Christian;Cihakova, Daniela
通讯作者：
Cihakova, Daniela