Phenomenological and microscopic theories for catch bonds.
Phenomenological and microscopic theories for catch bonds.
复制标题
DOI：
10.1016/j.jsb.2016.03.022
复制
发表时间：
2017-01
影响因子：
3
通讯作者：
Thirumalai D
中科院分区：
文献类型：
--
作者：
Chakrabarti S;Hinczewski M;Thirumalai D
当受到机械力时，蛋白质复合物或生物分子折叠态的结合态的寿命通常会降低。然而，大量的生物系统表现出捕获键合的反直觉现象，其中非共价键在外部施加的力下变得更强。对捕获键行为起源的探索导致了唯象和微观理论的发展，这些理论可以定量地概括实验数据。在这里，我们评估这些理论在解释实验数据的成功和局限性。最广泛应用的方法是一个现象学的两态模型，它适合所有可用的数据上的各种复合物：肌动球蛋白，kinetochore-microtubule，选择素配体，和钙粘蛋白-连环蛋白结合到丝状肌动蛋白。主要集中在选择素家族的细胞粘附复合物，我们讨论的积极和消极的现象学模型和评估的重要性，拟合参数的物理相关性。我们描述了一个微观理论选择素，它提供了一个结构基础，捕捉债券和预测残基Asn 82-Glu 88的重要变构作用。我们强调需要新的理论和模拟，可以模仿实验条件下，细胞粘附复合物的复杂反应力和它们在各种生物学背景下的潜在作用。
Lifetimes of bound states of protein complexes or biomolecule folded states typically decrease when subject to mechanical force. However, a plethora of biological systems exhibit the counter-intuitive phenomenon of catch bonding, where non-covalent bonds become stronger under externally applied forces. The quest to understand the origin of catch-bond behavior has led to the development of phenomenological and microscopic theories that can quantitatively recapitulate experimental data. Here, we assess the successes and limitations of such theories in explaining experimental data. The most widely applied approach is a phenomenological two-state model, which fits all of the available data on a variety of complexes: actomyosin, kinetochore-microtubule, selectin-ligand, and cadherin-catenin binding to filamentous actin. With a primary focus on the selectin family of cell-adhesion complexes, we discuss the positives and negatives of phenomenological models and the importance of evaluating the physical relevance of fitting parameters. We describe a microscopic theory for selectins, which provides a structural basis for catch bonds and predicts a crucial allosteric role for residues Asn82–Glu88. We emphasize the need for new theories and simulations that can mimic experimental conditions, given the complex response of cell adhesion complexes to force and their potential role in a variety of biological contexts.
登录
查看更多内容
DOI：
10.1083/jcb.200810002
发表时间：
2009-06-29
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kong F;García AJ;Mould AP;Humphries MJ;Zhu C
通讯作者：
Zhu C
影响因子：
2.4
作者：
Bartolo, D;Derényi, I;Ajdari, A
通讯作者：
Ajdari, A
DOI：
10.1098/rspb.1988.0038
发表时间：
1988-06-22
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DEMBO, M;TORNEY, DC;HAMMER, D
通讯作者：
HAMMER, D
DOI：
10.1126/science.1254211
发表时间：
2014-10-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buckley CD;Tan J;Anderson KL;Hanein D;Volkmann N;Weis WI;Nelson WJ;Dunn AR
通讯作者：
Dunn AR
影响因子：
64.5
作者：
Marsh M;Helenius A
通讯作者：
Helenius A